{"id":"W2058963865","doi":"10.1021/ja806222e","title":"A Fok I/DNA Machine that Duplicates its Analyte Gene Sequence","year":2008,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institute for Advanced Research","keywords":"Deoxyribozyme; Chemistry; Gene duplication; Hemin; Gene; DNA; Sequence (biology); Oligonucleotide; Recognition sequence; Molecular beacon; Sequence analysis; Duplex (building); Nucleic acid sequence; Nucleic acid; Cleavage (geology); Molecular biology; Biochemistry; Enzyme; Restriction enzyme; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000388053,0.000561669,0.0006296065,0.0004518276,0.0004506479,0.0007047346,0.001265788,0.0008684393,0.002007412],"category_scores_gemma":[0.0006009925,0.000518369,0.0003240377,0.000284214,0.000538211,0.0005448236,0.0005056518,0.001484274,0.002985655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005035842,"about_ca_system_score_gemma":0.0004284304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001936421,"about_ca_topic_score_gemma":0.0002393167,"domain_scores_codex":[0.9993201,0.00007400044,0.0000327401,0.0002589682,0.0002603862,0.00005375848],"domain_scores_gemma":[0.9996073,0.00009553256,0.0001017903,0.00008630088,0.00005232701,0.00005690193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006499858,0.00003482938,0.0002094458,0.0001333332,0.000008420243,0.00006342228,0.00002173404,0.0002042686,0.9824123,0.001356298,0.0007253265,0.01476571],"study_design_scores_gemma":[0.0000117857,0.0001217691,0.000276192,0.000007372533,0.00001106356,0.0004601527,0.000006481218,0.00282968,0.9774593,0.0003016005,0.01849704,0.00001762532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1869423,0.003864717,0.7842622,0.0006621096,0.0008736764,0.0005083162,0.0009625007,0.01365521,0.008269054],"genre_scores_gemma":[0.3080232,0.001401161,0.6684185,0.0004859127,0.0001016186,0.0008405833,0.001317169,0.0004920993,0.01891974],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002007412,"threshold_uncertainty_score":0.006715477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01906106475665326,"score_gpt":0.2805389212281129,"score_spread":0.2614778564714597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}