{"id":"W2058963865","doi":"10.1021/ja806222e","title":"A Fok I/DNA Machine that Duplicates its Analyte Gene Sequence","year":2008,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institute for Advanced Research","keywords":"Deoxyribozyme; Chemistry; Gene duplication; Hemin; Gene; DNA; Sequence (biology); Oligonucleotide; Recognition sequence; Molecular beacon; Sequence analysis; Duplex (building); Nucleic acid sequence; Nucleic acid; Cleavage (geology); Molecular biology; Biochemistry; Enzyme; Restriction enzyme; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001628636,0.0001554523,0.0002928614,0.00001306013,0.0001130374,0.000009923809,0.0004322731,0.00007175891,0.000001640091],"category_scores_gemma":[0.00008820576,0.00009474968,0.0007073194,0.0002548374,0.0005127563,0.000005797496,0.0001585673,0.0002367779,6.024566e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004786558,"about_ca_system_score_gemma":0.0000604111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008670561,"about_ca_topic_score_gemma":6.179769e-7,"domain_scores_codex":[0.9990382,0.00004104065,0.0002657345,0.0001949775,0.0002528361,0.0002072491],"domain_scores_gemma":[0.9988229,0.00001940838,0.0006096291,0.0002979061,0.0001575341,0.00009264642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004092142,0.0000428715,0.002509383,0.00000267247,0.0001490934,0.000003813081,0.00001848621,0.000005095286,0.992216,5.793983e-7,0.004301857,0.0007092427],"study_design_scores_gemma":[0.0001451191,0.00009346678,0.0008383257,0.000009967781,0.00006052946,0.0004205293,0.00002865518,0.0001068488,0.9934863,0.00003252471,0.004645267,0.0001323939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971287,0.0004543864,0.0008425539,0.001442908,0.00002518226,0.00004334771,0.00001333656,0.00001162817,0.000037985],"genre_scores_gemma":[0.9855385,0.001943328,0.01052417,0.001570151,0.0002420072,0.000001077945,0.000006689856,0.00001483234,0.0001592177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01159015,"threshold_uncertainty_score":0.386378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01906106475665326,"score_gpt":0.2805389212281129,"score_spread":0.2614778564714597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}