{"id":"W2058986667","doi":"10.1016/j.bmcl.2013.04.077","title":"Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Respiratory viral infections research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Boehringer Ingelheim (Canada)","funders":"KU Leuven","keywords":"Rhinovirus; Chemistry; Chemical synthesis; Biological activity; Combinatorial chemistry; In vitro; Pharmacology; Virus; Virology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002374367,0.0002702758,0.0002207477,0.0002124976,0.0002162274,0.0002881654,0.0003655475,0.0003367075,0.001011361],"category_scores_gemma":[0.0002167207,0.0001478366,0.0002596569,0.0001769551,0.0001623828,0.0001810262,0.0001345965,0.0003155461,0.0002422518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003543757,"about_ca_system_score_gemma":0.0003450674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007811937,"about_ca_topic_score_gemma":0.001857679,"domain_scores_codex":[0.9999095,0.00001904702,0.000009508749,0.0000125546,0.00002283716,0.00002644132],"domain_scores_gemma":[0.9999405,0.000009272871,0.00001593694,0.000005850787,0.00001475151,0.00001360168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003431257,0.0001490337,0.0001810736,0.000158494,0.00001451078,0.0002347672,0.00004832209,0.0011654,0.9876341,0.0003504887,0.0001245709,0.009596255],"study_design_scores_gemma":[0.0002144221,0.003137236,0.0009643434,0.00001831877,0.0000489549,0.0003553218,0.00003507997,0.001759476,0.9868909,0.00006867095,0.006492226,0.00001504808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857519,0.004952726,0.005539621,0.0001643176,0.00006020816,0.0002351678,0.0002756858,0.00006873228,0.002951803],"genre_scores_gemma":[0.9881167,0.003196062,0.006051165,0.00006096429,0.00001715806,0.00007007791,0.0003010335,0.00001037935,0.002176312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001011361,"threshold_uncertainty_score":0.003383398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1264900770058275,"score_gpt":0.3593677432953279,"score_spread":0.2328776662895004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}