{"id":"W2058988392","doi":"10.1038/ncomms6619","title":"An epigenomic roadmap to induced pluripotency reveals DNA methylation as a reprogramming modulator","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"College of Medicine, Seoul National University; Ministry of Knowledge Economy","keywords":"Reprogramming; Epigenomics; DNA methylation; Epigenetics; Induced pluripotent stem cell; Biology; DNA demethylation; Methylation; Cell biology; Histone; Somatic cell; Genetics; Embryonic stem cell; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001343723,0.0001462768,0.0001633924,0.0002749439,0.0001063035,0.0003081156,0.0001377758,0.000168962,0.001898641],"category_scores_gemma":[0.0002371378,0.0001650091,0.0001579686,0.0002107128,0.0001604926,0.0002660471,0.00026963,0.0003938338,0.0003381443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001991288,"about_ca_system_score_gemma":0.0001800227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004022495,"about_ca_topic_score_gemma":0.0009019636,"domain_scores_codex":[0.99992,0.000009178033,0.000003789862,0.00003141668,0.00002102219,0.00001455964],"domain_scores_gemma":[0.9998988,0.00002613346,0.00002241154,0.00001583337,0.00001681959,0.0000199944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007312596,0.000004852815,0.001710475,0.00002266899,0.000006500321,0.00003033855,0.00002464964,0.0002313307,0.9927025,0.0002705066,0.00004590053,0.004877169],"study_design_scores_gemma":[0.00001550712,0.0003016457,0.1562645,0.0000177347,0.00005571274,0.0004116265,0.0001001101,0.00609858,0.8276307,0.001334181,0.007752291,0.00001744219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9606589,0.001938401,0.03105576,0.0002354122,0.00002295349,0.00003817346,0.002176561,0.00030934,0.003564514],"genre_scores_gemma":[0.9846684,0.001040315,0.009627624,0.0001349509,0.00001262013,0.00004612416,0.001634072,0.00006833828,0.002767463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001898641,"threshold_uncertainty_score":0.00635159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02157827035408379,"score_gpt":0.3399182514286386,"score_spread":0.3183399810745548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}