{"id":"W2059086631","doi":"10.1093/ecam/nep069","title":"The Budding Yeast “<i>Saccharomyces cerevisiae</i>” as a Drug Discovery Tool to Identify Plant‐Derived Natural Products with Anti‐Proliferative Properties","year":2009,"lang":"en","type":"article","venue":"Evidence-based Complementary and Alternative Medicine","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"The Academy of Sciences for the Developing World","keywords":"Saccharomyces cerevisiae; Yeast; Budding yeast; Drug discovery; Biology; Computational biology; Cell cycle; Antifungal; Mechanism of action; Drug; Drug action; Gene; Cell biology; Biochemistry; Microbiology; Pharmacology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00073512,0.0004625497,0.0006414426,0.0001670184,0.0006359284,0.0001967906,0.000339119,0.00002477086,0.00008057387],"category_scores_gemma":[0.00060269,0.0002173932,0.00006199211,0.0004333868,0.0004333995,0.0007598692,0.00009837886,0.0003967061,0.00001078438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001017968,"about_ca_system_score_gemma":0.0001592564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004172002,"about_ca_topic_score_gemma":0.00006054105,"domain_scores_codex":[0.9971932,0.0002098246,0.0005396645,0.0008068941,0.0007429249,0.0005074469],"domain_scores_gemma":[0.9985521,0.0002786802,0.0002407404,0.0004098533,0.0003547488,0.0001638566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005129638,0.0001356517,0.002175536,0.0002704274,0.0003177596,0.000192744,0.001967685,0.00001013048,0.9677946,0.0004782278,0.00853181,0.01299582],"study_design_scores_gemma":[0.003437786,0.003947016,0.0281945,0.01162547,0.0004083191,0.0002586584,0.002958489,0.0001932787,0.939352,0.0001461166,0.00881512,0.0006631989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8402965,0.006331879,0.00003594063,0.151173,0.0003057602,0.001728968,0.00003994139,0.00004988442,0.0000381054],"genre_scores_gemma":[0.9873076,0.0008328141,0.0004432384,0.009367835,0.001367546,0.00001698332,0.00007234319,0.0000210355,0.0005705906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1470111,"threshold_uncertainty_score":0.8865037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0451092204559906,"score_gpt":0.3039907375863833,"score_spread":0.2588815171303928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}