{"id":"W2059086631","doi":"10.1093/ecam/nep069","title":"The Budding Yeast “<i>Saccharomyces cerevisiae</i>” as a Drug Discovery Tool to Identify Plant‐Derived Natural Products with Anti‐Proliferative Properties","year":2009,"lang":"en","type":"article","venue":"Evidence-based Complementary and Alternative Medicine","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"The Academy of Sciences for the Developing World","keywords":"Saccharomyces cerevisiae; Yeast; Budding yeast; Drug discovery; Biology; Computational biology; Cell cycle; Antifungal; Mechanism of action; Drug; Drug action; Gene; Cell biology; Biochemistry; Microbiology; Pharmacology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003440918,0.0004361928,0.0005312471,0.0007500302,0.0003587397,0.0004504431,0.0003764535,0.0002595403,0.001138266],"category_scores_gemma":[0.0001590368,0.0002326704,0.0003726697,0.0006402609,0.0002539929,0.0002295634,0.0003648973,0.0007165747,0.0007829216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002306817,"about_ca_system_score_gemma":0.0003630003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006856645,"about_ca_topic_score_gemma":0.001913962,"domain_scores_codex":[0.9997614,0.00006267686,0.00002688417,0.00004007621,0.00008757241,0.00002129658],"domain_scores_gemma":[0.999905,0.00002669141,0.00001679039,0.00001749987,0.00001562716,0.00001841917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001089799,0.00007200058,0.0003185181,0.0002033921,0.0000168082,0.0001356285,0.00002238574,0.0002448084,0.9844393,0.001195196,0.0005050656,0.01273791],"study_design_scores_gemma":[0.00002850464,0.0003204274,0.0008538614,0.00002879005,0.00003607485,0.0004348149,0.00003036483,0.0007489534,0.970058,0.0002642487,0.02718438,0.00001158613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6879855,0.05196765,0.2234422,0.002517133,0.000701478,0.001468681,0.00931401,0.001955606,0.0206478],"genre_scores_gemma":[0.6962921,0.0297225,0.2591023,0.0005875012,0.00006118593,0.0004671423,0.005580728,0.0001824265,0.008004017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001138266,"threshold_uncertainty_score":0.003807902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0451092204559906,"score_gpt":0.3039907375863833,"score_spread":0.2588815171303928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}