{"id":"W2059087146","doi":"10.1002/(sici)1097-0045(20000301)42:4<260::aid-pros3>3.0.co;2-0","title":"Heterogeneous apoptotic responses of prostate cancer cell lines identify an association between sensitivity to staurosporine-induced apoptosis, expression of Bcl-2 family members, and caspase activation","year":2000,"lang":"en","type":"article","venue":"The Prostate","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ryerson University","keywords":"Staurosporine; Apoptosis; Biology; Cytochrome c; Caspase; LNCaP; Programmed cell death; Poly ADP ribose polymerase; DNA fragmentation; Cell biology; Cell culture; Intrinsic apoptosis; Molecular biology; Cancer cell; Signal transduction; Biochemistry; Cancer; Protein kinase C; Genetics; Polymerase; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001541617,0.0002362459,0.00026386,0.0003861861,0.0001651464,0.0003349948,0.0001711862,0.0002216654,0.0008960532],"category_scores_gemma":[0.0001543031,0.0001336655,0.000214506,0.0003088594,0.0001725308,0.0001411783,0.0001680599,0.0004302842,0.0002541498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003030069,"about_ca_system_score_gemma":0.0001958883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007707576,"about_ca_topic_score_gemma":0.001492243,"domain_scores_codex":[0.9997672,0.00003095445,0.00002734502,0.00004460094,0.00009407558,0.00003582003],"domain_scores_gemma":[0.9998214,0.00003734833,0.00004046915,0.00003178411,0.00003670606,0.00003234696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001244543,0.00004296354,0.002745318,0.00003062835,0.00001826485,0.0000581854,0.0000307348,0.00005320702,0.9959208,0.00003203934,0.00002590078,0.0009174797],"study_design_scores_gemma":[0.0000209635,0.0008594342,0.06119682,0.00000492261,0.00005028077,0.001306327,0.00008542498,0.0006407448,0.9345078,0.00003985753,0.001280785,0.00000674492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961125,0.001289117,0.001445065,0.00003962949,0.000006303752,0.00002878351,0.0005151805,0.0000440566,0.000519412],"genre_scores_gemma":[0.9977338,0.0004057376,0.0006176967,0.00003125164,0.000003957347,0.00002890905,0.0007744424,0.00000576605,0.0003983348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008960532,"threshold_uncertainty_score":0.002997637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01478804010857705,"score_gpt":0.2779169329246391,"score_spread":0.2631288928160621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}