{"id":"W2059087146","doi":"10.1002/(sici)1097-0045(20000301)42:4<260::aid-pros3>3.0.co;2-0","title":"Heterogeneous apoptotic responses of prostate cancer cell lines identify an association between sensitivity to staurosporine-induced apoptosis, expression of Bcl-2 family members, and caspase activation","year":2000,"lang":"en","type":"article","venue":"The Prostate","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ryerson University","keywords":"Staurosporine; Apoptosis; Biology; Cytochrome c; Caspase; LNCaP; Programmed cell death; Poly ADP ribose polymerase; DNA fragmentation; Cell biology; Cell culture; Intrinsic apoptosis; Molecular biology; Cancer cell; Signal transduction; Biochemistry; Cancer; Protein kinase C; Genetics; Polymerase; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004652737,0.0001423673,0.0001819392,0.0000320279,0.00009159261,0.00001923848,0.00006124494,0.0001073886,0.00001018066],"category_scores_gemma":[0.00003139925,0.0001097346,0.00004412543,0.00008702465,0.00002372966,0.00001938154,0.00005082319,0.00005477106,5.998568e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003212006,"about_ca_system_score_gemma":0.00004272731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006638627,"about_ca_topic_score_gemma":0.0001026677,"domain_scores_codex":[0.998872,0.0002159928,0.0002747552,0.0002669693,0.0001964246,0.0001738103],"domain_scores_gemma":[0.9992417,0.00003634646,0.0002477151,0.0002518025,0.0001576625,0.00006482438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005233614,0.00004681262,0.001946876,0.00004869578,0.00002435769,3.864613e-7,0.0006505268,0.001029135,0.9869084,7.808356e-7,0.00002773765,0.00879298],"study_design_scores_gemma":[0.0004046277,0.0003128393,0.02514367,0.00004389936,0.00004679513,9.396335e-7,0.0001210167,0.0001265798,0.9734316,0.00002789038,0.0002139493,0.0001261505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988708,0.000160523,0.00008006221,0.0001104101,0.00005177496,0.0005397234,0.0001604767,0.00001030503,0.00001585377],"genre_scores_gemma":[0.9981033,0.000669305,0.0001714494,0.00003660699,0.00007883448,0.00002467744,0.0001268162,0.00002162956,0.0007673353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02319679,"threshold_uncertainty_score":0.4474847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01478804010857705,"score_gpt":0.2779169329246391,"score_spread":0.2631288928160621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}