{"id":"W2059124078","doi":"10.1016/j.bbagrm.2010.09.002","title":"DNA methylation and demethylation probed by small molecules","year":2010,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; DNA demethylation; Biology; Epigenetics of physical exercise; RNA-Directed DNA Methylation; Epigenomics; DNA methyltransferase; Methylation; Epigenetics; DNA; DNMT1; Methyltransferase; Molecular biology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005786165,0.001376216,0.001454715,0.0008779484,0.0002594703,0.0005703122,0.001035265,0.001168219,0.001407271],"category_scores_gemma":[0.0004997586,0.0005373542,0.0003486132,0.001015912,0.0008311548,0.000953351,0.0006531239,0.001796816,0.002040365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008534542,"about_ca_system_score_gemma":0.0005037395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007533568,"about_ca_topic_score_gemma":0.00132264,"domain_scores_codex":[0.9998676,0.00001930509,0.00001005173,0.00003824812,0.00004613216,0.00001867937],"domain_scores_gemma":[0.9998554,0.00007706905,0.00001758405,0.00001065349,0.00002703539,0.00001219981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003023791,0.0001463763,0.0002557481,0.0103862,0.0001199864,0.0006026565,0.0001038967,0.001102893,0.2309945,0.01527687,0.02458246,0.7161261],"study_design_scores_gemma":[0.00006631218,0.0001543027,0.0008835631,0.0005042998,0.0001310164,0.001446736,0.00005323366,0.0006454398,0.1716062,0.005582486,0.8188729,0.00005361645],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00170419,0.98834,0.004071952,0.0004893435,0.0005576824,0.00002164402,0.00006276905,0.0000496445,0.004702752],"genre_scores_gemma":[0.01031417,0.9797001,0.002445238,0.0004505442,0.000340356,0.0000652046,0.000142606,0.00001302696,0.006528829],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001454715,"threshold_uncertainty_score":0.006192207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02070891828961214,"score_gpt":0.2768429020741587,"score_spread":0.2561339837845465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}