{"id":"W2059124237","doi":"10.1158/0008-5472.can-07-6168","title":"Inflammatory Signaling and Aryl Hydrocarbon Receptor Mediate Synergistic Induction of Interleukin 6 in MCF-7 Cells","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Center for Research Resources; National Institute of Environmental Health Sciences","keywords":"Aryl hydrocarbon receptor; Signal transduction; Chromatin immunoprecipitation; Biology; Gene silencing; Cell biology; Immune system; Interleukin; Chromatin; Cytokine; Regulation of gene expression; Transcription factor; Gene expression; Cancer research; Immunology; Biochemistry; Promoter; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001236078,0.0001369584,0.0003470365,0.000552962,0.0000772937,0.000006445534,0.00009433511,0.0001548993,0.0001266367],"category_scores_gemma":[0.0002775714,0.0001233321,0.00004213062,0.0004518619,0.0003974504,0.0000894102,0.00006907195,0.0006772075,0.00002235802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002850056,"about_ca_system_score_gemma":0.0004357965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000409448,"about_ca_topic_score_gemma":0.00006199255,"domain_scores_codex":[0.9981472,0.0001660781,0.0003688029,0.0003009293,0.0006034835,0.0004135158],"domain_scores_gemma":[0.9990515,0.0002585799,0.00007816734,0.0002239234,0.0001776573,0.0002101428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004763025,0.00004887669,0.02640922,0.0005185775,0.00002616215,0.0001758929,0.001865701,0.00004031587,0.9677566,0.00003204421,0.0007425385,0.001907818],"study_design_scores_gemma":[0.00177062,0.0003272823,0.014635,0.0008919291,0.00001401695,0.0000178891,0.000268659,0.0003008189,0.9804388,0.00005347668,0.001130344,0.0001512055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974541,0.001282269,0.000004228679,0.0001444239,0.000363798,0.0004877638,0.00000423462,0.00002237452,0.000236772],"genre_scores_gemma":[0.9978845,0.001284854,0.00003487763,0.00002970363,0.0004138729,0.0001212379,0.000006060826,0.00003101146,0.0001939047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01268221,"threshold_uncertainty_score":0.5029337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05155310298445211,"score_gpt":0.3408307847200843,"score_spread":0.2892776817356322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}