{"id":"W2059157689","doi":"10.1371/journal.pone.0086919","title":"Pharmacogenetic-Based Efavirenz Dose Modification: Suggestions for an African Population and the Different CYP2B6 Genotypes","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University; University of British Columbia; HIV Legal Network","funders":"Canadian Institutes of Health Research; Karolinska Institutet; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Efavirenz; CYP2B6; Pharmacokinetics; NONMEM; Genotype; Pharmacology; Population; Pharmacogenetics; Medicine; Biology; Internal medicine; Virology; Viral load; Human immunodeficiency virus (HIV); Antiretroviral therapy; Genetics; CYP3A4; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001406568,0.0001182514,0.000208584,0.00005867263,0.0001662809,0.00002249427,0.00004699469,0.00003289122,0.00002774135],"category_scores_gemma":[0.00006054112,0.00007400907,0.00003674625,0.00006887152,0.00005519222,0.00002943279,0.000009764621,0.00004908372,0.000009376768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003503314,"about_ca_system_score_gemma":0.0000207422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001526445,"about_ca_topic_score_gemma":0.00001922917,"domain_scores_codex":[0.9992551,0.00006632747,0.0001616466,0.0001926906,0.0001927031,0.0001314821],"domain_scores_gemma":[0.9994126,0.00014442,0.00005705345,0.00020694,0.00007492189,0.0001040692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0109415,0.03001606,0.6106759,0.001085737,0.003820431,0.000005540976,0.006784971,0.0002282234,0.121291,0.0161533,0.001897063,0.1971003],"study_design_scores_gemma":[0.03067803,0.0008400144,0.7403684,0.0002220969,0.002985312,0.000003601948,0.00009683227,0.1400831,0.0800268,0.001952985,0.002244038,0.000498823],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891183,0.0002034194,0.0007545857,0.00838891,0.0000171103,0.001171593,0.00001294735,0.00005998618,0.0002730962],"genre_scores_gemma":[0.99423,0.00005934419,0.003621299,0.0001939657,0.0001245008,0.0004288757,0.0003393647,0.00001750224,0.0009850879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1966015,"threshold_uncertainty_score":0.3018002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06498660881589974,"score_gpt":0.2847850319854382,"score_spread":0.2197984231695385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}