{"id":"W2059196610","doi":"10.1021/jm050955y","title":"Diadenosine and Diuridine Poly(borano)phosphate Analogues:  Synthesis, Chemical and Enzymatic Stability, and Activity at P2Y<sub>1</sub> and P2Y<sub>2</sub> Receptors","year":2006,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Stereochemistry; Nucleotide; Receptor; Chemical synthesis; Enzyme; Nucleoside; Hydrolysis; Chemical stability; Lead compound; Biochemistry; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006181434,0.0003851321,0.0006116292,0.00005456326,0.0001403529,0.00004594595,0.0001391368,0.0003266085,0.00001491684],"category_scores_gemma":[0.0003931089,0.0003274156,0.00009275154,0.0001131717,0.0005189889,0.0000303935,0.0002252384,0.000388708,3.567868e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005467705,"about_ca_system_score_gemma":0.00009419142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001833106,"about_ca_topic_score_gemma":0.000005521165,"domain_scores_codex":[0.9981069,0.00007489762,0.0005882196,0.0004696731,0.0003852558,0.0003750451],"domain_scores_gemma":[0.9985781,0.000210901,0.000456869,0.0002194884,0.000142841,0.0003918154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004863247,0.0001067523,0.008142123,0.0004189071,0.000108297,0.00006065304,0.00005296102,0.000001364058,0.9849164,0.000001302836,0.001811435,0.0038935],"study_design_scores_gemma":[0.001330634,0.0002192857,0.004307786,0.0002821479,0.0002591574,0.001232322,0.0001149305,0.00003874169,0.991376,0.00006721225,0.0004462543,0.0003254705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627407,0.03621077,0.0001001607,0.0006745874,0.00007534643,0.00009842793,0.00002232256,0.000009197564,0.0000685195],"genre_scores_gemma":[0.9923489,0.006438576,0.0001197826,0.00008454799,0.000924267,0.000005843508,0.00002716177,0.00003408095,0.00001680832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0297722,"threshold_uncertainty_score":0.9999178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006440461381813821,"score_gpt":0.2077391077293645,"score_spread":0.2012986463475507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}