{"id":"W2059196610","doi":"10.1021/jm050955y","title":"Diadenosine and Diuridine Poly(borano)phosphate Analogues:  Synthesis, Chemical and Enzymatic Stability, and Activity at P2Y<sub>1</sub> and P2Y<sub>2</sub> Receptors","year":2006,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Stereochemistry; Nucleotide; Receptor; Chemical synthesis; Enzyme; Nucleoside; Hydrolysis; Chemical stability; Lead compound; Biochemistry; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000177207,0.0003679363,0.0002553989,0.0001162847,0.0001164689,0.0002507109,0.0002553631,0.0003327232,0.0008646025],"category_scores_gemma":[0.0002113273,0.0001590693,0.0001493232,0.000200123,0.0001574816,0.000320561,0.0001850095,0.0003677846,0.0002822183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002357006,"about_ca_system_score_gemma":0.0001649695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000296542,"about_ca_topic_score_gemma":0.0004754358,"domain_scores_codex":[0.9998705,0.00002230876,0.0000166097,0.00004019167,0.00002811271,0.00002225806],"domain_scores_gemma":[0.999905,0.00001798121,0.00003016839,0.00001125187,0.000009840708,0.00002573548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002576119,0.0000247521,0.0002008814,0.0001536667,0.000008497969,0.00009183174,0.0000346629,0.0002585212,0.9842784,0.0004846686,0.00005813065,0.01414831],"study_design_scores_gemma":[0.00002030313,0.0005719322,0.0008950228,0.00000654713,0.00002035301,0.0003932476,0.00001133831,0.0004904788,0.9910696,0.0000716944,0.006441273,0.000008233058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9494471,0.03196708,0.01219388,0.0001004096,0.00007877597,0.0001090294,0.0003894782,0.000110591,0.00560372],"genre_scores_gemma":[0.9736944,0.008006928,0.01396087,0.00008078184,0.00003343364,0.0001256568,0.0005227232,0.00002857094,0.003546632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008646025,"threshold_uncertainty_score":0.002892375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006440461381813821,"score_gpt":0.2077391077293645,"score_spread":0.2012986463475507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}