{"id":"W2059222694","doi":"10.1021/bi701957c","title":"Kinetic and Structural Analysis of Bisubstrate Inhibition of the <i>Salmonella enterica </i>Aminoglycoside 6‘-<i>N</i>-Acetyltransferase<sup>,</sup>","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Salmonella enterica; Aminoglycoside; Acetyltransferase; Salmonella; Chemistry; Microbiology; Biochemistry; Antibiotics; Escherichia coli; Biology; Bacteria; Genetics; Gene; Acetylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000243659,0.0004226237,0.0004237088,0.0002133844,0.0001743388,0.0003544534,0.000670447,0.000311545,0.001151474],"category_scores_gemma":[0.0005358437,0.0003149678,0.0004001187,0.0004773385,0.0002135399,0.0003194368,0.0001410118,0.0008419666,0.0005052174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001216812,"about_ca_system_score_gemma":0.0004144512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006965903,"about_ca_topic_score_gemma":0.005366978,"domain_scores_codex":[0.9996808,0.00003822923,0.00002406234,0.00006501994,0.0001273033,0.00006461216],"domain_scores_gemma":[0.9995927,0.00008337503,0.000114592,0.00002615373,0.00012932,0.00005383878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007625836,0.0004590904,0.002247536,0.0001300135,0.00006803983,0.00007373528,0.0001152864,0.006279201,0.9834922,0.0006978583,0.0005641074,0.005110451],"study_design_scores_gemma":[0.00002805699,0.0005638661,0.007312857,0.00000782796,0.00003234025,0.00009133037,0.00004903822,0.02943054,0.9601722,0.00006426512,0.002220249,0.00002736339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934556,0.001062491,0.002274064,0.00009065533,0.00002824627,0.00002120863,0.00107672,0.00006682688,0.001924174],"genre_scores_gemma":[0.992623,0.0008483295,0.00211117,0.00002637382,0.000005533898,0.00002868574,0.002853256,0.00004874363,0.001454967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006965903,"threshold_uncertainty_score":0.01385069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006884933365703615,"score_gpt":0.2437380110802392,"score_spread":0.2368530777145356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}