{"id":"W2059222694","doi":"10.1021/bi701957c","title":"Kinetic and Structural Analysis of Bisubstrate Inhibition of the <i>Salmonella enterica </i>Aminoglycoside 6‘-<i>N</i>-Acetyltransferase<sup>,</sup>","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Salmonella enterica; Aminoglycoside; Acetyltransferase; Salmonella; Chemistry; Microbiology; Biochemistry; Antibiotics; Escherichia coli; Biology; Bacteria; Genetics; Gene; Acetylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001909711,0.0001925651,0.0002560081,0.00006474394,0.00005017484,0.00001143821,0.0002219228,0.0002275807,0.0000196877],"category_scores_gemma":[0.00006136021,0.0001506335,0.0002566188,0.0004951744,0.000437516,0.000002633866,0.0001546937,0.0001357822,3.069698e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001156377,"about_ca_system_score_gemma":0.00004811076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004309349,"about_ca_topic_score_gemma":0.000007443089,"domain_scores_codex":[0.9986463,0.00003444042,0.0003796301,0.00038283,0.0002698759,0.0002868826],"domain_scores_gemma":[0.9991477,0.00001955736,0.0001195536,0.0004701499,0.0001263146,0.0001167183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001403229,0.00004319124,0.006735022,0.0001061977,0.000270765,0.000002664101,0.00003230247,0.00005111611,0.9920492,0.000009082526,0.00007564265,0.0004845475],"study_design_scores_gemma":[0.0003847728,0.00007479847,0.008807005,0.00002780004,0.0002092383,0.00001496211,0.00007068382,0.0001921305,0.9898893,0.00001492026,0.0001579566,0.0001564017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978426,0.0009827743,0.0004318625,0.00006197135,0.00001667287,0.0001325566,0.00009847791,0.000006056859,0.0004270862],"genre_scores_gemma":[0.999227,0.0001165626,0.0002065825,0.00007707463,0.00005183032,0.000004851636,0.000179629,0.00001569884,0.0001207934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002159816,"threshold_uncertainty_score":0.6142657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006884933365703615,"score_gpt":0.2437380110802392,"score_spread":0.2368530777145356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}