{"id":"W2059299942","doi":"10.1021/bi050493q","title":"Mutational Analysis of a Nucleosidase Involved in Quorum-Sensing Autoinducer-2 Biosynthesis","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Hospital for Sick Children","keywords":"Quorum sensing; Autoinducer; Biosynthesis; Chemistry; Computational biology; Biochemistry; Biology; Gene; Virulence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001368071,0.0001273953,0.0001897324,0.0001243177,0.00002654398,0.000008314288,0.0001027037,0.0001888481,0.0000844631],"category_scores_gemma":[0.00004434104,0.0001399824,0.0001887399,0.0003559142,0.000068902,0.000003281371,0.00002228246,0.00006229112,0.000002904694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002745762,"about_ca_system_score_gemma":0.00007469227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000452182,"about_ca_topic_score_gemma":0.0001974074,"domain_scores_codex":[0.999088,0.00001812926,0.0002966898,0.0002963269,0.0001368254,0.0001639903],"domain_scores_gemma":[0.9995157,0.000011246,0.00009731376,0.0002594484,0.00006080618,0.00005547672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004915144,0.00007686052,0.009291254,0.00001898144,0.0001816936,0.000003942022,0.0000553319,0.000236735,0.9886088,0.00000703624,0.00002305749,0.001447168],"study_design_scores_gemma":[0.0002797605,0.00001582024,0.01338143,0.00001659851,0.0001552926,0.000002076076,0.00009922131,0.003010429,0.9817014,0.000005403017,0.001172523,0.0001600948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978247,0.0003663305,0.001095289,0.0001376266,0.00001903771,0.00005170378,0.00003896558,0.000009193579,0.0004571278],"genre_scores_gemma":[0.9960102,0.00002853424,0.001318048,0.00006599125,0.00009441743,0.000002299259,0.002329592,0.00001232332,0.0001386161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00690744,"threshold_uncertainty_score":0.5708315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009192822037220313,"score_gpt":0.2291080200766717,"score_spread":0.2199151980394514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}