{"id":"W2059299942","doi":"10.1021/bi050493q","title":"Mutational Analysis of a Nucleosidase Involved in Quorum-Sensing Autoinducer-2 Biosynthesis","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Hospital for Sick Children","keywords":"Quorum sensing; Autoinducer; Biosynthesis; Chemistry; Computational biology; Biochemistry; Biology; Gene; Virulence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002080106,0.0005955654,0.0003303986,0.0002625813,0.0001683156,0.000353137,0.0003815917,0.0004762805,0.0008773943],"category_scores_gemma":[0.0004054099,0.0001303153,0.0004588353,0.0002591429,0.0002657515,0.0001346291,0.000253775,0.000438032,0.0005422914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004438175,"about_ca_system_score_gemma":0.0003454961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001516409,"about_ca_topic_score_gemma":0.000960063,"domain_scores_codex":[0.9998232,0.00005414255,0.0000235701,0.00002215186,0.00005292183,0.00002410433],"domain_scores_gemma":[0.9996554,0.0001328917,0.00009157321,0.00001916314,0.00003574511,0.00006535435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002929623,0.0001141687,0.001054231,0.00008734247,0.00002724784,0.001036197,0.00005211416,0.0007526976,0.9937654,0.0003195461,0.00007309725,0.002425062],"study_design_scores_gemma":[0.00004655536,0.0004000654,0.01029267,0.00003580236,0.00007651134,0.001874726,0.0001067622,0.005923674,0.9782974,0.0001412089,0.00277431,0.00003027735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936986,0.0005779748,0.003575877,0.00009968839,0.00003592059,0.00006027648,0.0006840295,0.00006347938,0.001204212],"genre_scores_gemma":[0.9958006,0.0003085471,0.002461985,0.00003750125,0.00001006589,0.00001885926,0.000735209,0.00003368317,0.0005935584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001516409,"threshold_uncertainty_score":0.003220141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009192822037220313,"score_gpt":0.2291080200766717,"score_spread":0.2199151980394514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}