{"id":"W2059357684","doi":"10.1073/pnas.1101194108","title":"Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Vetenskapsrådet; Uppsala Universitet; Cancerfonden; European Commission; Mizutani Foundation for Glycoscience","keywords":"Transthyretin; Heparan sulfate; Heparin; Chinese hamster ovary cell; Chemistry; Amyloidosis; Tetramer; Amyloid (mycology); Biochemistry; Retinol binding protein; Fibril; Mutant; Amyloid disease; Cell biology; Biology; Amyloid fibril; Internal medicine; Gene; Endocrinology; Amyloid β; Receptor; Retinol; Medicine; Vitamin; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008312232,0.0001275024,0.0001380931,0.0001000325,0.0001424319,0.00001839676,0.0006671523,0.00009790067,0.000005859029],"category_scores_gemma":[0.000441932,0.00007791584,0.00007587022,0.0008171176,0.0003241015,0.00004432462,0.00007785849,0.00008663758,0.000001572914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000028093,"about_ca_system_score_gemma":0.00003692385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004370795,"about_ca_topic_score_gemma":0.000002574397,"domain_scores_codex":[0.998658,0.00002396505,0.0002757586,0.0003220007,0.0005310947,0.0001892026],"domain_scores_gemma":[0.9995505,0.00003257562,0.0002340973,0.00001644699,0.000144307,0.00002202322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005908874,0.000151033,0.09822775,0.00003905428,0.00003068449,1.457414e-8,0.002458226,0.00003227284,0.8905931,0.007959517,0.0002117558,0.0002374752],"study_design_scores_gemma":[0.0001893282,0.0001838996,0.1250689,0.00006436416,0.00001058858,0.000003670443,0.0003221931,0.00002987981,0.8695981,0.004346631,0.00009784746,0.00008463503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943417,0.00008149862,0.000006921518,0.001906989,0.000007540862,0.000750736,0.00001342539,0.000005623333,0.002885604],"genre_scores_gemma":[0.9976637,0.00003145377,0.00188707,0.0002224683,0.00003340503,0.00009686676,8.983451e-7,0.000006608371,0.00005747603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0268411,"threshold_uncertainty_score":0.3177316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04895054847075547,"score_gpt":0.3035986720449311,"score_spread":0.2546481235741757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}