{"id":"W2059357684","doi":"10.1073/pnas.1101194108","title":"Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Vetenskapsrådet; Uppsala Universitet; Cancerfonden; European Commission; Mizutani Foundation for Glycoscience","keywords":"Transthyretin; Heparan sulfate; Heparin; Chinese hamster ovary cell; Chemistry; Amyloidosis; Tetramer; Amyloid (mycology); Biochemistry; Retinol binding protein; Fibril; Mutant; Amyloid disease; Cell biology; Biology; Amyloid fibril; Internal medicine; Gene; Endocrinology; Amyloid β; Receptor; Retinol; Medicine; Vitamin; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009985973,0.0002690799,0.0001150714,0.0001222443,0.0001155881,0.000150248,0.0001004756,0.0001229411,0.0005874153],"category_scores_gemma":[0.00004720645,0.00009199941,0.0002063412,0.00006132301,0.000142728,0.0001040521,0.0001935683,0.0002574039,0.0001489364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001802381,"about_ca_system_score_gemma":0.0001277578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001297937,"about_ca_topic_score_gemma":0.002176239,"domain_scores_codex":[0.9999318,0.00001514068,0.000004745998,0.000009567323,0.00001943485,0.00001929846],"domain_scores_gemma":[0.9999563,0.000005252237,0.00001002718,0.000005372515,0.000006753376,0.00001625785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002208115,0.000008745012,0.00008614068,0.000008266465,0.000002194931,0.00003507742,0.000009080615,0.00001017419,0.9994898,0.00002905952,0.000009698372,0.0002896737],"study_design_scores_gemma":[0.000007618631,0.0001915093,0.005915322,0.000003650171,0.000009167825,0.0001487836,0.00002080776,0.000680129,0.9921122,0.00002775973,0.0008806444,0.000002414008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973109,0.0006190639,0.001064166,0.00004024269,0.000009935016,0.00001510351,0.00004846766,0.00002199287,0.0008699864],"genre_scores_gemma":[0.9961613,0.0003785762,0.001066029,0.00002822548,0.000005447371,0.000009684972,0.0001048929,0.000006927764,0.00223886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001297937,"threshold_uncertainty_score":0.002580762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04895054847075547,"score_gpt":0.3035986720449311,"score_spread":0.2546481235741757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}