{"id":"W2059367897","doi":"10.1073/pnas.1311120110","title":"Design and formulation of functional pluripotent stem cell-derived cardiac microtissues","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":295,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Tissue engineering; Stem cell; Biomedical engineering; Organ-on-a-chip; Computational biology; Cell biology; Neuroscience; Biology; Nanotechnology; Embryonic stem cell; Medicine; Materials science; Gene; Microfluidics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004772817,0.00006887364,0.0001739651,0.0001118696,0.00006578886,0.000005156975,0.0000862644,0.00004807314,0.00001399161],"category_scores_gemma":[0.00005768953,0.00004023844,0.00003868505,0.0002378772,0.0003215752,0.0001492183,0.00002998574,0.0000788706,7.041792e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001660174,"about_ca_system_score_gemma":0.00001943629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005155371,"about_ca_topic_score_gemma":1.831543e-9,"domain_scores_codex":[0.998976,0.000004827607,0.0002239829,0.0001227171,0.0005940929,0.00007837055],"domain_scores_gemma":[0.9993773,0.00006873463,0.0001901644,0.000005386438,0.0003244539,0.0000339748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001030046,0.00001982038,0.002520611,0.0001232867,0.00001560725,1.752971e-9,0.0002543819,0.0006947583,0.993552,0.001670183,0.0005354007,0.0006037043],"study_design_scores_gemma":[0.0002547312,0.0001145546,0.1592317,0.0001230853,0.00002508438,0.000005364562,0.0002110022,0.003924535,0.8352957,0.0006852316,0.000089015,0.00003993561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957415,0.00165937,0.0001947248,0.001757926,0.00003065048,0.0003702883,0.000002093212,0.000007709746,0.0002357674],"genre_scores_gemma":[0.9936367,0.00005068342,0.005266979,0.00001926313,0.00007819173,0.0000119228,1.923678e-7,0.000003256286,0.0009327949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1582562,"threshold_uncertainty_score":0.1640876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04239876334698203,"score_gpt":0.2658360282360355,"score_spread":0.2234372648890535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}