{"id":"W2059410730","doi":"10.1073/pnas.0510441103","title":"Mutation and genomic deletion status of <i>ataxia telangiectasia mutated</i> ( <i>ATM</i> ) and <i>p53</i> confer specific gene expression profiles in mantle cell lymphoma","year":2006,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute; National Institutes of Health; University of Southern California; V Foundation for Cancer Research; Lymphoma Research Foundation","keywords":"Biology; Gene; Genetics; Allele; Mantle cell lymphoma; Ataxia-telangiectasia; Phenotype; Mutation; Cancer research; Cyclin D1; Point mutation; Molecular biology; Cell cycle; Lymphoma; DNA damage; DNA; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001441998,0.0001248773,0.0001257057,0.0005546142,0.000111169,0.0002341338,0.00007492935,0.000166614,0.0004934079],"category_scores_gemma":[0.0004904005,0.0001525533,0.0000682658,0.0002008038,0.0002219266,0.0001303597,0.000125315,0.0001684605,0.0001416578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001378101,"about_ca_system_score_gemma":0.00007036766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004279113,"about_ca_topic_score_gemma":0.0006426693,"domain_scores_codex":[0.999882,0.00002501529,0.00001108815,0.00002664398,0.00002653216,0.00002868712],"domain_scores_gemma":[0.9998168,0.00005616428,0.00005639937,0.0000120872,0.00001399674,0.00004464694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001044233,0.00009520289,0.3287016,0.00004277589,0.00003087055,0.001156313,0.0001791707,0.0002609283,0.6584231,0.00006821723,0.00009778977,0.009899869],"study_design_scores_gemma":[0.00001675249,0.0003480212,0.9603142,0.000004263251,0.00003702651,0.005012313,0.0001685344,0.0004509789,0.03323735,0.00006215705,0.0003427534,0.000005608536],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996752,0.00009227389,0.00006313186,0.000004972192,5.205277e-7,0.000001111383,0.00002499307,0.000003448854,0.0001345294],"genre_scores_gemma":[0.9996541,0.00008315431,0.00009228857,0.000005467164,0.000002309155,0.000002553913,0.00008405423,0.000001298034,0.00007479326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005546142,"threshold_uncertainty_score":0.001650631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181990482587423,"score_gpt":0.2550573883710656,"score_spread":0.2368583401123233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}