{"id":"W2059410730","doi":"10.1073/pnas.0510441103","title":"Mutation and genomic deletion status of <i>ataxia telangiectasia mutated</i> ( <i>ATM</i> ) and <i>p53</i> confer specific gene expression profiles in mantle cell lymphoma","year":2006,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute; National Institutes of Health; University of Southern California; V Foundation for Cancer Research; Lymphoma Research Foundation","keywords":"Biology; Gene; Genetics; Allele; Mantle cell lymphoma; Ataxia-telangiectasia; Phenotype; Mutation; Cancer research; Cyclin D1; Point mutation; Molecular biology; Cell cycle; Lymphoma; DNA damage; DNA; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003141732,0.0001038144,0.0001984077,0.0001623838,0.00007161815,0.00001477,0.00009284911,0.00007128731,0.000005159961],"category_scores_gemma":[0.00003187809,0.00006921057,0.00003451079,0.0002876081,0.000403918,0.0001990676,0.00005743932,0.00004294547,4.89555e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008229773,"about_ca_system_score_gemma":0.00004685226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008309203,"about_ca_topic_score_gemma":3.695103e-7,"domain_scores_codex":[0.9987338,0.000007052984,0.0003431184,0.0002387583,0.0005205247,0.0001567416],"domain_scores_gemma":[0.9994192,0.00006711013,0.0003322889,0.000009884153,0.0001329683,0.0000385217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006733218,0.0002452482,0.1543647,0.0001298043,0.000006044497,1.955304e-7,0.0001724931,0.00001730447,0.8423508,0.00146327,0.0004240469,0.000758764],"study_design_scores_gemma":[0.001110895,0.0000658412,0.4060042,0.0001019002,0.00001469749,0.00002729201,0.0001096344,0.000115826,0.5906869,0.001585769,0.0001351699,0.00004188497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950929,0.002066353,7.186546e-7,0.000319701,0.000008811451,0.0003435788,0.00004285509,0.000006273443,0.002118854],"genre_scores_gemma":[0.9972242,0.000564618,0.002054618,0.0000618791,0.00002982478,0.00001794198,0.000003852301,0.000005160546,0.00003789261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.251664,"threshold_uncertainty_score":0.2822325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181990482587423,"score_gpt":0.2550573883710656,"score_spread":0.2368583401123233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}