{"id":"W2059437739","doi":"10.1242/dev.054916","title":"Impaired mesenchymal stem cell differentiation and osteoclastogenesis in mice deficient for <i>Igf2-P2</i> transcripts","year":2010,"lang":"en","type":"article","venue":"Development","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Connaught Fund","keywords":"Biology; Mesenchymal stem cell; Cell biology; Embryonic stem cell; Cellular differentiation; Progenitor cell; Osteoblast; Transcription factor; Osteopontin; Mutant; Stem cell; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000134953,0.0001500508,0.0001158453,0.00005311253,0.0000811024,0.00002535521,0.0001090486,0.0001127677,0.000005458703],"category_scores_gemma":[0.00001006441,0.0001483511,0.00004211776,0.00005003423,0.00002692922,0.000003453692,0.00004386857,0.00004950085,0.000002535365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001745305,"about_ca_system_score_gemma":0.0001475371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000432656,"about_ca_topic_score_gemma":0.0001780543,"domain_scores_codex":[0.9990659,0.00002237351,0.0002365258,0.0003305165,0.0001128829,0.0002317469],"domain_scores_gemma":[0.999669,0.00001544409,0.00005681311,0.0001291144,0.00004504991,0.00008458293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008302325,0.0001204539,0.01010795,0.00006898459,0.00001485404,8.532127e-7,0.0004540294,0.00001669027,0.982744,0.000006685344,0.0001338579,0.006248642],"study_design_scores_gemma":[0.0008121428,0.00005302498,0.06059037,0.00001183899,0.00001377057,0.000002554338,0.0001026952,0.00004964233,0.9262989,0.000004179052,0.01186147,0.0001993842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996973,0.000424676,0.001940607,0.00003168519,0.0002174761,0.0003336022,0.00001808285,0.00001299066,0.000047897],"genre_scores_gemma":[0.9960898,0.000009582756,0.00328449,0.00007969821,0.00004147899,0.0001294863,0.0001424602,0.00002003665,0.0002029756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05644504,"threshold_uncertainty_score":0.6049584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009041331763828417,"score_gpt":0.2101461006114795,"score_spread":0.201104768847651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}