{"id":"W2059459126","doi":"10.1016/j.nmd.2010.03.006","title":"Progressive skeletal muscle weakness in transgenic mice expressing CTG expansions is associated with the activation of the ubiquitin–proteasome pathway","year":2010,"lang":"en","type":"article","venue":"Neuromuscular Disorders","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Myotonic dystrophy; Wasting; Skeletal muscle; Weakness; Endocrinology; Internal medicine; Proteasome; Muscular dystrophy; Muscle weakness; Atrophy; Biology; Transgene; Genetically modified mouse; Ubiquitin; Sarcopenia; Muscle atrophy; Medicine; Anatomy; Gene; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001517367,0.0009312295,0.0002980605,0.0008661514,0.0002273033,0.0002486821,0.000227222,0.0006609663,0.001884317],"category_scores_gemma":[0.0001538882,0.0002540975,0.0003501145,0.0002883649,0.0005919907,0.000186482,0.0003190977,0.0007039201,0.0005938341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003493968,"about_ca_system_score_gemma":0.0002435777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001153102,"about_ca_topic_score_gemma":0.001809672,"domain_scores_codex":[0.999851,0.00002372595,0.00001931759,0.00004247405,0.00004154585,0.00002187762],"domain_scores_gemma":[0.9997662,0.00002763723,0.0001291651,0.00001244162,0.00001626073,0.00004838639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001705036,0.00002191295,0.0003744112,0.00003022649,0.00001481267,0.000660241,0.00001304615,0.00007052819,0.9977004,0.0001049018,0.0001104564,0.0007284755],"study_design_scores_gemma":[0.0002318733,0.0005011431,0.07694937,0.00007590456,0.0002094797,0.01350787,0.00008263867,0.003058993,0.9012774,0.0006114729,0.003458765,0.00003505548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932655,0.001166054,0.003008147,0.0002036938,0.00004092799,0.00003091611,0.0006603978,0.0001991393,0.001425197],"genre_scores_gemma":[0.9929572,0.0008479651,0.00200191,0.0001164952,0.00002519266,0.00005806877,0.0007441921,0.00007800159,0.003171034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001884317,"threshold_uncertainty_score":0.006303668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01193724919396026,"score_gpt":0.2302377857538299,"score_spread":0.2183005365598696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}