{"id":"W2059459126","doi":"10.1016/j.nmd.2010.03.006","title":"Progressive skeletal muscle weakness in transgenic mice expressing CTG expansions is associated with the activation of the ubiquitin–proteasome pathway","year":2010,"lang":"en","type":"article","venue":"Neuromuscular Disorders","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Myotonic dystrophy; Wasting; Skeletal muscle; Weakness; Endocrinology; Internal medicine; Proteasome; Muscular dystrophy; Muscle weakness; Atrophy; Biology; Transgene; Genetically modified mouse; Ubiquitin; Sarcopenia; Muscle atrophy; Medicine; Anatomy; Gene; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001552473,0.0002833593,0.0002200684,0.00008589643,0.0003966696,0.00006765777,0.0006983521,0.00008910409,0.00005329153],"category_scores_gemma":[0.0008462442,0.000174185,0.0001980701,0.0008514946,0.0005765547,0.000214889,0.0001020801,0.0005699723,0.000002561458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001497694,"about_ca_system_score_gemma":0.0001651306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002778382,"about_ca_topic_score_gemma":0.0001845568,"domain_scores_codex":[0.9972444,0.000738786,0.0002810139,0.000635152,0.0006912262,0.0004094679],"domain_scores_gemma":[0.9985486,0.0003368586,0.0002842325,0.000675017,0.0000831353,0.00007213511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001727174,0.0003133171,0.0008831657,0.00001662334,0.000007184907,0.000002817666,0.001291522,0.0004255372,0.9953108,0.0000605562,0.00002041459,0.001650745],"study_design_scores_gemma":[0.0007828564,0.00008082005,0.1073427,0.0000661764,0.0000291582,0.000002905224,0.0003263246,0.0003320458,0.89041,0.0001326545,0.0002879205,0.0002064039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958843,0.00002879239,0.00007391163,0.002254259,0.0002151366,0.001318226,0.00004105531,0.00004728106,0.0001370447],"genre_scores_gemma":[0.9989148,0.000006816796,0.00001945065,0.000683276,0.00002888012,0.0002483571,0.000003939659,0.00005657299,0.00003786146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1064595,"threshold_uncertainty_score":0.7103058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01193724919396026,"score_gpt":0.2302377857538299,"score_spread":0.2183005365598696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}