{"id":"W2059460453","doi":"10.1021/cb300655w","title":"Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor","year":2013,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Wellcome Trust","keywords":"BMPR2; Activin receptor; Bone morphogenetic protein; Receptor; Cell biology; Signal transduction; Kinase; Fibrodysplasia ossificans progressiva; Biology; Chemistry; Biochemistry; Heterotopic ossification; Gene; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002163589,0.0004404776,0.0002920278,0.0002560445,0.0001616612,0.0002688776,0.0005029538,0.000379267,0.001817274],"category_scores_gemma":[0.0001045081,0.0002395795,0.0002050294,0.0001610309,0.000150384,0.0002164788,0.0001882381,0.000585461,0.0006832246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003282586,"about_ca_system_score_gemma":0.0004412231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005326667,"about_ca_topic_score_gemma":0.001148596,"domain_scores_codex":[0.9998471,0.00001875374,0.00001171718,0.00003691332,0.00005491132,0.0000305689],"domain_scores_gemma":[0.999961,0.000004285737,0.000009577461,0.000004522489,0.000008885217,0.00001173939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001483416,0.0001418334,0.0001309786,0.00005374003,0.00001533716,0.00007503771,0.00001044282,0.0003431528,0.9893189,0.0005374451,0.0002883276,0.008936399],"study_design_scores_gemma":[0.0001386814,0.0006618031,0.0004831711,0.000005178096,0.00003278127,0.0005293511,0.000007927728,0.002134813,0.9861473,0.00006007914,0.009790615,0.000008237536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9156594,0.005595453,0.05415004,0.0007761377,0.0002752006,0.001001923,0.001207623,0.0005890125,0.0207453],"genre_scores_gemma":[0.9528766,0.003879843,0.02889552,0.0003519309,0.00004296474,0.0004191613,0.001307227,0.00005576608,0.012171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001817274,"threshold_uncertainty_score":0.006079435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02682733193736347,"score_gpt":0.2964301431429453,"score_spread":0.2696028112055818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}