{"id":"W2059539545","doi":"10.1016/j.ecoenv.2006.06.012","title":"The H295R system for evaluation of endocrine-disrupting effects","year":2006,"lang":"en","type":"article","venue":"Ecotoxicology and Environmental Safety","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Institut National de la Recherche Scientifique","funders":"","keywords":"Hormone; Endocrine system; Inducer; Mode of action; Steroid hormone; Gene expression; Steroid; Chemistry; Signal transduction; Biology; Gene; Endocrinology; Internal medicine; Pharmacology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008257897,0.0001438692,0.0001782429,0.00001176562,0.0004209379,0.000009966509,0.0001286738,0.00006303222,0.00007903296],"category_scores_gemma":[0.00006860101,0.0001001248,0.00009318596,0.00003692511,0.0003625247,0.00006596708,0.0001432418,0.00008198182,0.00001923878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002006107,"about_ca_system_score_gemma":0.000004040352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006475665,"about_ca_topic_score_gemma":0.00006281184,"domain_scores_codex":[0.9987628,0.0001393408,0.0002967658,0.0002714871,0.0002236017,0.0003060457],"domain_scores_gemma":[0.9989102,0.0007124789,0.0001548545,0.0001735317,0.000002852546,0.00004608161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004557899,0.0005054391,0.1849617,0.0002778687,0.0001316535,0.000009831656,0.000170758,0.007477341,0.7025874,0.002911413,0.002106322,0.09840446],"study_design_scores_gemma":[0.006953042,0.0006144723,0.6060227,0.00007501342,0.0004653007,0.000117723,0.0006356269,0.02194117,0.3412527,0.002760153,0.01855229,0.000609833],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936619,0.0005321593,0.0001033349,0.0001214163,0.0001640881,0.0008597186,0.00002072209,0.00002134497,0.00451532],"genre_scores_gemma":[0.999145,0.00005073314,0.0003428616,0.0000244788,0.00006543126,0.0001536081,0.00003204219,0.00001339809,0.0001724354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.421061,"threshold_uncertainty_score":0.4082972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005055337152435359,"score_gpt":0.2823560998899777,"score_spread":0.2773007627375424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}