{"id":"W2059551149","doi":"10.1038/nature09789","title":"Crystal structure of metarhodopsin II","year":2011,"lang":"en","type":"article","venue":"Nature","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":668,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"","keywords":"Transducin; Rhodopsin; Heterotrimeric G protein; Schiff base; Chemistry; Opsin; Retinaldehyde; G protein-coupled receptor; Retinal; Ligand (biochemistry); Stereochemistry; Biophysics; G protein; Crystallography; Receptor; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004845987,0.00008363544,0.00009565053,0.00002066755,0.00003683345,0.000002628377,0.0001353166,0.0007703704,0.0006087233],"category_scores_gemma":[0.00002722396,0.00006741163,0.0000708674,0.00004737061,0.00002653024,0.000001696699,0.00006298073,0.0003400624,6.908274e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002496067,"about_ca_system_score_gemma":0.0000262737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007012253,"about_ca_topic_score_gemma":0.000007596147,"domain_scores_codex":[0.9995394,0.00001912515,0.0000946034,0.0001547961,0.00008761136,0.0001044075],"domain_scores_gemma":[0.9996766,0.000001551082,0.0000518415,0.0001739482,0.00006282469,0.00003320166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003492073,0.00001506156,0.000107863,0.00000692989,0.00003257603,7.092461e-7,0.00009033522,0.000002143836,0.9971936,0.001387859,0.0008469253,0.0002810796],"study_design_scores_gemma":[0.0001408874,0.0001531121,0.0003302854,0.000004555197,0.00001245874,0.000006245603,0.00003414227,0.000001858027,0.9838145,0.0009624812,0.01445911,0.00008033857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952595,0.001286788,0.0004220232,0.0000139669,0.0002617863,0.00005665595,0.00003112592,0.00000570703,0.002662423],"genre_scores_gemma":[0.992651,0.00001674196,0.006603376,0.0001782422,0.0001332833,6.351268e-7,0.00004317779,0.00001116279,0.0003624003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01361218,"threshold_uncertainty_score":0.6665093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009179170606410218,"score_gpt":0.2289999854418168,"score_spread":0.2198208148354066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}