{"id":"W2059551149","doi":"10.1038/nature09789","title":"Crystal structure of metarhodopsin II","year":2011,"lang":"en","type":"article","venue":"Nature","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":668,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"","keywords":"Transducin; Rhodopsin; Heterotrimeric G protein; Schiff base; Chemistry; Opsin; Retinaldehyde; G protein-coupled receptor; Retinal; Ligand (biochemistry); Stereochemistry; Biophysics; G protein; Crystallography; Receptor; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001872774,0.0003530327,0.0005238351,0.0001409327,0.0004098991,0.0009556996,0.0004764203,0.0003101947,0.001494729],"category_scores_gemma":[0.0003739364,0.0002197941,0.0001499653,0.0002596786,0.0001985546,0.0002385244,0.0001902271,0.001302683,0.0004015388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001013239,"about_ca_system_score_gemma":0.0009773201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006952234,"about_ca_topic_score_gemma":0.007195852,"domain_scores_codex":[0.9999269,0.000008231948,0.000004164665,0.00001706651,0.00002678259,0.00001673243],"domain_scores_gemma":[0.9999142,0.0000126279,0.00001568899,0.000004388592,0.0000202861,0.00003279397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001886612,0.0002825511,0.005719446,0.0007567275,0.0001588994,0.002043268,0.0006101673,0.00806269,0.9054871,0.01696308,0.0320754,0.02595397],"study_design_scores_gemma":[0.001952348,0.001337983,0.06570429,0.0004429436,0.0004585426,0.004368461,0.003183776,0.09225225,0.5841364,0.01068621,0.2351229,0.0003538878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.951053,0.01190399,0.005816076,0.002942564,0.001036956,0.00006957175,0.004122505,0.0005592823,0.02249605],"genre_scores_gemma":[0.9673948,0.005120454,0.004264494,0.000586087,0.00009117894,0.00004908997,0.007961039,0.00006854087,0.01446432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006952234,"threshold_uncertainty_score":0.01382351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009179170606410218,"score_gpt":0.2289999854418168,"score_spread":0.2198208148354066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}