{"id":"W2059583288","doi":"10.1021/bi200731e","title":"Relative and Regional Stabilities of the Hamster, Mouse, Rabbit, and Bovine Prion Proteins toward Urea Unfolding Assessed by Nuclear Magnetic Resonance and Circular Dichroism Spectroscopies","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; National Institute for Nanotechnology; University of Toronto; Ontario Institute for Cancer Research; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Circular dichroism; Chemistry; Urea; Nuclear magnetic resonance spectroscopy; Hamster; Denaturation (fissile materials); Protein structure; Protein secondary structure; Biophysics; Crystallography; Biochemistry; Molecular biology; Stereochemistry; Biology; Nuclear chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001126393,0.0001778891,0.0001594053,0.00001341262,0.0001132738,0.00002739984,0.0001311247,0.000154014,0.00001949739],"category_scores_gemma":[0.0001076603,0.0001492182,0.00004820583,0.00004819674,0.0004254169,0.00001225259,0.0002240965,0.0001020722,1.455997e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001397497,"about_ca_system_score_gemma":0.0000578903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005436276,"about_ca_topic_score_gemma":0.00000209715,"domain_scores_codex":[0.9990804,0.0000438453,0.0001905112,0.0003766638,0.0001295887,0.0001790533],"domain_scores_gemma":[0.9994456,0.00001389384,0.0001174253,0.0002864163,0.00004912688,0.00008758417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001192436,0.00003800823,0.006146608,0.0002411095,0.00002218953,9.560811e-7,0.0002511136,3.276638e-8,0.9916394,0.0000975982,0.0002330652,0.001210678],"study_design_scores_gemma":[0.0005967988,0.0002310314,0.009628363,0.000129747,0.000032805,0.00002263631,0.0003841925,0.00001463198,0.9850159,0.0003449838,0.00337926,0.0002196646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.921773,0.07754778,0.00004257905,0.0001626427,0.00001489256,0.000252977,0.00005605743,0.0000102781,0.0001397541],"genre_scores_gemma":[0.9946712,0.004245777,0.0006907546,0.0000729463,0.00003920188,0.00001960448,0.00001701602,0.0000209199,0.0002225274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07330201,"threshold_uncertainty_score":0.6084943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228691322786023,"score_gpt":0.2061456368961415,"score_spread":0.1938587236682813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}