{"id":"W2059583288","doi":"10.1021/bi200731e","title":"Relative and Regional Stabilities of the Hamster, Mouse, Rabbit, and Bovine Prion Proteins toward Urea Unfolding Assessed by Nuclear Magnetic Resonance and Circular Dichroism Spectroscopies","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; National Institute for Nanotechnology; University of Toronto; Ontario Institute for Cancer Research; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Circular dichroism; Chemistry; Urea; Nuclear magnetic resonance spectroscopy; Hamster; Denaturation (fissile materials); Protein structure; Protein secondary structure; Biophysics; Crystallography; Biochemistry; Molecular biology; Stereochemistry; Biology; Nuclear chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004339087,0.0002390401,0.0002190658,0.0003197524,0.0001438062,0.000295384,0.0001517893,0.0002782463,0.0004251384],"category_scores_gemma":[0.0004745581,0.0001526083,0.0002822326,0.0001951323,0.000199807,0.0001927649,0.0001821221,0.000329968,0.0001312569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001629636,"about_ca_system_score_gemma":0.00008373141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004668538,"about_ca_topic_score_gemma":0.000525224,"domain_scores_codex":[0.9998273,0.00002762348,0.00002814215,0.0000531598,0.00003656757,0.00002720401],"domain_scores_gemma":[0.9996564,0.0000585888,0.0001379152,0.00003975796,0.00004983119,0.00005755178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008778919,0.000006699027,0.000949794,0.00002114703,0.00001103976,0.00002480659,0.0000499078,0.00002863019,0.9983338,0.00003443995,0.000009339734,0.000442602],"study_design_scores_gemma":[0.00001969331,0.0009921539,0.1039235,0.00002257595,0.0001182743,0.00109706,0.000132754,0.00108357,0.8905782,0.0001073473,0.001905784,0.00001918492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981183,0.00091352,0.0005476298,0.00001473724,0.0000044301,0.000005213665,0.0001323958,0.00001144511,0.0002524621],"genre_scores_gemma":[0.995787,0.0007768134,0.001898255,0.00005416942,0.000007551299,0.00001690478,0.0007452937,0.00001372874,0.0007002153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004668538,"threshold_uncertainty_score":0.002294719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228691322786023,"score_gpt":0.2061456368961415,"score_spread":0.1938587236682813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}