{"id":"W2059590573","doi":"10.1021/ja908372b","title":"Unnatural Amino Acid Substitution as a Probe of the Allosteric Coupling Pathway in a Mycobacterial Cu(I) Sensor","year":2009,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Electrochemical Analysis and Applications","field":"Chemistry","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Chemistry; Allosteric regulation; Substitution (logic); Coupling (piping); Combinatorial chemistry; Stereochemistry; Biophysics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001711823,0.000156642,0.0002036323,0.00005760109,0.0001437747,0.0002157156,0.0003133496,0.0003564649,0.0008214008],"category_scores_gemma":[0.0002705019,0.0001157091,0.00009746721,0.0001002274,0.0003435698,0.0001578683,0.0001771553,0.0005466015,0.0001316138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002775958,"about_ca_system_score_gemma":0.0001538711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004017295,"about_ca_topic_score_gemma":0.000416562,"domain_scores_codex":[0.9998589,0.00003290907,0.00001252705,0.00003502367,0.00003597775,0.0000246346],"domain_scores_gemma":[0.9998856,0.00003235156,0.0000326802,0.00001982154,0.000008955271,0.00002061639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002302873,0.00004246383,0.0001158905,0.0000211657,0.000003786915,0.0000555294,0.00001826845,0.0001419226,0.9984225,0.0002228584,0.00002310708,0.0007022849],"study_design_scores_gemma":[0.00003509233,0.0002312485,0.0004626031,0.000002107118,0.000006425193,0.00009217697,0.00001081956,0.001103152,0.9974391,0.00005795957,0.0005546655,0.000004676032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972439,0.0001913622,0.001621102,0.00009091219,0.00002404563,0.00001214969,0.00004183514,0.00004003329,0.0007347529],"genre_scores_gemma":[0.9975066,0.0001212513,0.00185987,0.00005114636,0.000004642732,0.00001070364,0.00003194162,0.00001346482,0.0004005504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008214008,"threshold_uncertainty_score":0.002747893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007401655006759494,"score_gpt":0.2357230556152697,"score_spread":0.2283214006085102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}