{"id":"W2059623829","doi":"10.1007/bf03261913","title":"Effect of Ketoconazole on the Pharmacokinetic Profile of Buprenorphine following Administration of a Once-Weekly Buprenorphine Transdermal System","year":2012,"lang":"en","type":"article","venue":"Clinical Drug Investigation","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"","keywords":"Ketoconazole; Medicine; Buprenorphine; Cmax; Pharmacokinetics; Placebo; Crossover study; Pharmacology; Confidence interval; Transdermal; Area under the curve; Anesthesia; Internal medicine; Opioid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00604179,0.0003200526,0.0007887338,0.0001207485,0.0001222751,0.000006657837,0.0004217228,0.000284381,0.0002454942],"category_scores_gemma":[0.0005593367,0.0002333179,0.0004580106,0.0003883893,0.0006057911,0.0001537373,0.00006436494,0.0007383915,0.00003016263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002887877,"about_ca_system_score_gemma":0.0001467661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000179921,"about_ca_topic_score_gemma":0.00000140866,"domain_scores_codex":[0.9944679,0.002684447,0.001697821,0.0003084475,0.0004373776,0.0004040307],"domain_scores_gemma":[0.9946814,0.003488692,0.0009809522,0.0003423176,0.0001598892,0.0003467915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004030833,0.001806106,0.08532561,0.002242987,0.001082954,0.00001082048,0.002644867,0.001450156,0.8517414,0.005986188,0.002416053,0.04126202],"study_design_scores_gemma":[0.003880614,0.0007929891,0.01370611,0.0001817934,0.001065648,0.000005483314,0.00008814583,0.01099709,0.9673689,0.00008702775,0.001609391,0.0002168322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931711,0.0006927102,0.00005487024,0.0006994632,0.001933771,0.001532765,0.0001610712,0.00004612841,0.001708129],"genre_scores_gemma":[0.9985144,0.00009021947,0.0001398661,0.0003296298,0.0005474792,0.0001564567,0.00007561308,0.00003340878,0.0001129694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1156275,"threshold_uncertainty_score":0.9514429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1064207797096589,"score_gpt":0.4382565665593631,"score_spread":0.3318357868497042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}