{"id":"W2059633613","doi":"10.1097/01.fpc.0000173484.51807.48","title":"Functional characterization of non-synonymous single nucleotide polymorphisms in the gene encoding human multidrug resistance protein 1 (MRP1/ABCC1)","year":2005,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"ABCC1; Single-nucleotide polymorphism; Biology; Genetics; Mutant; Gene; Efflux; ATP-binding cassette transporter; Mutagenesis; Wild type; Multidrug Resistance-Associated Proteins; Transporter; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002601773,0.0001677352,0.0002290943,0.0001035568,0.0001234411,0.00001948453,0.0001060763,0.00005952542,0.00004524491],"category_scores_gemma":[0.000002921295,0.0001388814,0.00006510929,0.0001412662,0.00007864643,0.00004845094,0.00001943468,0.0001450518,0.000003823908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005493299,"about_ca_system_score_gemma":0.00004759793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000812625,"about_ca_topic_score_gemma":0.0000509631,"domain_scores_codex":[0.9988719,0.00002729853,0.0004010186,0.0002481268,0.000221786,0.000229917],"domain_scores_gemma":[0.999528,0.0000133613,0.0001451402,0.0001773424,0.00005891524,0.00007727032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001629773,0.0002373902,0.001074922,0.00006343247,0.0000253197,0.00001594798,0.0008578555,0.00004469482,0.9946086,0.00008734737,0.00001609654,0.002805424],"study_design_scores_gemma":[0.001725575,0.00007120032,0.04054614,0.00007502885,0.00009145284,0.0000130848,0.00007819164,0.0007383903,0.9482871,0.00006023045,0.008133541,0.0001800614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961401,0.000500018,0.001339458,0.0007432892,0.0001020137,0.0006329049,0.00004317886,0.0000134058,0.0004855935],"genre_scores_gemma":[0.9950791,0.0003500172,0.002868249,0.0003544708,0.0003729795,0.00003012203,0.0001041492,0.00003043323,0.0008104783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04632149,"threshold_uncertainty_score":0.5663417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02080394875278669,"score_gpt":0.2486905487021202,"score_spread":0.2278865999493335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}