{"id":"W2059637489","doi":"10.1021/op0002904","title":"Development and Scale Up of a Route to Cyclohexylhydrazine Dimethanesulfonate","year":2000,"lang":"en","type":"article","venue":"Organic Process Research & Development","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Energy","funders":"","keywords":"Methanesulfonic acid; Chemistry; Decarboxylation; Cyclohexanone; Carboxylate; Hydrazine (antidepressant); Organic chemistry; Hydrolysis; Borane; Hydrazone; Derivatization; Medicinal chemistry; Catalysis; Chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007224581,0.0001673459,0.0002370875,0.0001044449,0.0001538935,0.00003170991,0.0003205394,0.0001021532,0.0004660299],"category_scores_gemma":[0.0001113276,0.0001450341,0.00003291033,0.0005027787,0.00008259402,0.000005908963,0.0002426337,0.0001186318,0.00007876778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005372256,"about_ca_system_score_gemma":0.0004335923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001352999,"about_ca_topic_score_gemma":0.00008047134,"domain_scores_codex":[0.9980748,0.00004571598,0.0003645518,0.0005099103,0.0005529172,0.00045214],"domain_scores_gemma":[0.9992189,0.0000202769,0.00004003561,0.0002376997,0.0002266559,0.0002563646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001009953,0.00009086425,0.0008647997,0.00006862568,0.0000818952,0.000001780984,0.0009676166,0.000002423651,0.8473946,0.000002992087,0.0001926537,0.1502308],"study_design_scores_gemma":[0.0002680543,0.00003373541,0.00295356,0.0000491117,0.000005807778,0.000004448275,0.0001417665,0.000004033805,0.8984228,0.00003097348,0.09790295,0.0001827619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975864,0.0003628915,0.0001191973,0.0002207939,0.00001098428,0.0001797705,0.00000360981,0.000009888643,0.001506503],"genre_scores_gemma":[0.9901686,0.0002646958,0.004529158,0.00007315619,0.00003948517,0.00006934235,0.00004221304,0.00002532001,0.004788023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.150048,"threshold_uncertainty_score":0.591432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01745773250405917,"score_gpt":0.3108292598503544,"score_spread":0.2933715273462952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}