{"id":"W2059643491","doi":"10.1016/j.yexcr.2006.09.026","title":"Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes","year":2006,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Biology; Cancer research; Germline; Epithelium; Ovarian cancer; DNA damage; Tumor suppressor gene; Somatic cell; Germline mutation; Apoptosis; Malignant transformation; Cell biology; DNA repair; Neoplastic transformation; Mutation; Cancer; Gene; Genetics; Carcinogenesis; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002009473,0.0003878424,0.000254176,0.0008576297,0.0002464849,0.0004352375,0.0001819012,0.0004930945,0.003128368],"category_scores_gemma":[0.0002186297,0.000353553,0.0002943767,0.0002306971,0.0004843858,0.0003071393,0.0002842688,0.00095596,0.0005881971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000342568,"about_ca_system_score_gemma":0.0002666998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007995467,"about_ca_topic_score_gemma":0.0008815318,"domain_scores_codex":[0.9997781,0.0000264524,0.00001787377,0.00005819935,0.00006629451,0.0000531136],"domain_scores_gemma":[0.9994975,0.00009714039,0.0001660958,0.00007267595,0.00003279688,0.0001337576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001112859,0.00001609024,0.0002321016,0.00001784909,0.000004661913,0.00006514812,0.0000128608,0.00003421608,0.9988604,0.0001508627,0.00002686847,0.0004677212],"study_design_scores_gemma":[0.00001093926,0.00009269183,0.004009538,0.000003858191,0.00001349874,0.0003307645,0.00002983041,0.0002055466,0.9942592,0.00007453121,0.0009664479,0.000003109352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905938,0.00204191,0.00393251,0.0002285158,0.00004576684,0.00002920712,0.001022034,0.0003577591,0.001748545],"genre_scores_gemma":[0.9912934,0.0007659079,0.001702345,0.00006270183,0.000008029569,0.00002456135,0.0006720856,0.00005929067,0.00541171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003128368,"threshold_uncertainty_score":0.01046544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05563758563004235,"score_gpt":0.3713350074016593,"score_spread":0.315697421771617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}