{"id":"W2059706140","doi":"10.1038/ng1605","title":"Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis","year":2005,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":206,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; University of Windsor; Mount Sinai Hospital","funders":"","keywords":"Biology; Mitosis; Haploinsufficiency; Cell biology; Carcinogenesis; Cell cycle; Loss of heterozygosity; Cancer research; Genetics; Cell; Cancer; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009930322,0.0001977453,0.0001450266,0.00004764416,0.00009956737,0.00003171344,0.0001935361,0.0004820731,0.00001072881],"category_scores_gemma":[0.00005885293,0.000190765,0.00006844353,0.00009250528,0.00008949547,0.000002965639,0.0001568786,0.0002177947,0.000009315855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001693076,"about_ca_system_score_gemma":0.00007761143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007995222,"about_ca_topic_score_gemma":0.0001881323,"domain_scores_codex":[0.9989151,0.00003158576,0.0002055088,0.000416232,0.0001426401,0.0002889185],"domain_scores_gemma":[0.9992834,0.000008989708,0.00005861432,0.0004170647,0.0001167053,0.0001152278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000378656,0.0001620903,0.07800368,0.0000471649,0.00007455513,0.000004076032,0.0001220891,0.0005596229,0.8978862,0.0001159484,0.003726673,0.01926],"study_design_scores_gemma":[0.0007813357,0.0003003218,0.09825756,0.00001563806,0.0001010808,0.00007125224,0.0000851384,0.0008683037,0.6415064,0.00007581973,0.2573271,0.000610031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739307,0.02456645,0.0004656903,0.0001818293,0.0001761501,0.0001546238,0.00003444354,0.00001798557,0.0004721569],"genre_scores_gemma":[0.9912371,0.003236074,0.003445454,0.001204576,0.0005543523,0.000007004987,0.00005502246,0.00002849008,0.0002319126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2563799,"threshold_uncertainty_score":0.7779171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006296244554547237,"score_gpt":0.2437701557181083,"score_spread":0.2374739111635611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}