{"id":"W2059706140","doi":"10.1038/ng1605","title":"Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis","year":2005,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":206,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; University of Windsor; Mount Sinai Hospital","funders":"","keywords":"Biology; Mitosis; Haploinsufficiency; Cell biology; Carcinogenesis; Cell cycle; Loss of heterozygosity; Cancer research; Genetics; Cell; Cancer; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002377302,0.0006161635,0.0004377517,0.001152981,0.0004961745,0.0007153698,0.0006004105,0.0007157203,0.005984053],"category_scores_gemma":[0.0003144574,0.0005778108,0.0003721375,0.0004800025,0.0006098979,0.000313265,0.0007387605,0.001195441,0.0008657916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005995493,"about_ca_system_score_gemma":0.000517396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001663695,"about_ca_topic_score_gemma":0.001866456,"domain_scores_codex":[0.9996824,0.00004702557,0.00004750685,0.00006889659,0.00007552549,0.00007860242],"domain_scores_gemma":[0.9995117,0.0001074567,0.0001163679,0.00009562534,0.00002532621,0.0001433873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003480031,0.00006581419,0.0007068993,0.00003904148,0.00001686375,0.0005363483,0.00001939928,0.0003395541,0.9950045,0.0006590358,0.0002418203,0.002022709],"study_design_scores_gemma":[0.00004915583,0.0001457444,0.005866533,0.000008665159,0.00003414521,0.001680029,0.0000578606,0.001808551,0.9864703,0.000284,0.003584232,0.00001087041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991115,0.0009691297,0.002696607,0.0004119556,0.00008461364,0.0000463717,0.001094089,0.0003946022,0.003187628],"genre_scores_gemma":[0.9940117,0.0003826958,0.0009015336,0.00007587266,0.00001359039,0.00002583442,0.0003705202,0.00008397802,0.00413416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005984053,"threshold_uncertainty_score":0.02001858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006296244554547237,"score_gpt":0.2437701557181083,"score_spread":0.2374739111635611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}