{"id":"W2059714799","doi":"10.1248/bpb.31.1312","title":"The Naturally Occurring Flavolignan, Deoxypodophyllotoxin, Inhibits Lipopolysaccharide-Induced iNOS Expression through the NF-&amp;kappa;B Activation in RAW264.7 Macrophage Cells","year":2008,"lang":"en","type":"article","venue":"Biological and Pharmaceutical Bulletin","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Nitric oxide synthase; Nitric oxide; Lipopolysaccharide; Western blot; Molecular biology; NFKB1; Chemistry; Transcription factor; Macrophage; NF-κB; Gene expression; Signal transduction; Biology; Biochemistry; Gene; In vitro; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005286307,0.0003090476,0.0002492942,0.00002040579,0.0005963372,0.00005762964,0.00035712,0.0003764966,0.00007539089],"category_scores_gemma":[0.0002851391,0.0001533247,0.0001213558,0.00009709346,0.0003939893,0.000009768002,0.0003475343,0.0005127415,0.00004139456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001867323,"about_ca_system_score_gemma":0.00003154417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004712482,"about_ca_topic_score_gemma":0.000009139284,"domain_scores_codex":[0.9977739,0.0005684207,0.0003710316,0.0005624363,0.0002004407,0.0005237908],"domain_scores_gemma":[0.9990063,0.0004181863,0.0001231728,0.0002657385,0.0000526692,0.0001339336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003565494,0.0001233197,0.0005491594,0.00000878753,0.0000188305,0.000008049787,0.00006503992,0.000002459094,0.9931633,0.00005044005,0.001111941,0.004542151],"study_design_scores_gemma":[0.0004429251,0.0001161031,0.001453513,0.00003181128,0.000006572515,0.00002913352,0.00004513584,0.00001415798,0.8553555,0.00006447526,0.142209,0.000231657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959705,0.001108608,0.0002254804,0.001786921,0.0001490067,0.0004436696,0.000020927,0.00002134385,0.0002735562],"genre_scores_gemma":[0.9953837,0.002048751,0.0002142847,0.001874643,0.0002793476,0.00005477948,0.00002203812,0.00001379534,0.0001086486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1410971,"threshold_uncertainty_score":0.6252398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0557591110724094,"score_gpt":0.2855236704611807,"score_spread":0.2297645593887712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}