{"id":"W2059714799","doi":"10.1248/bpb.31.1312","title":"The Naturally Occurring Flavolignan, Deoxypodophyllotoxin, Inhibits Lipopolysaccharide-Induced iNOS Expression through the NF-&amp;kappa;B Activation in RAW264.7 Macrophage Cells","year":2008,"lang":"en","type":"article","venue":"Biological and Pharmaceutical Bulletin","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Nitric oxide synthase; Nitric oxide; Lipopolysaccharide; Western blot; Molecular biology; NFKB1; Chemistry; Transcription factor; Macrophage; NF-κB; Gene expression; Signal transduction; Biology; Biochemistry; Gene; In vitro; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008409181,0.0002756597,0.00012713,0.0001240945,0.00006873973,0.000102725,0.00007252605,0.0001197123,0.0004406317],"category_scores_gemma":[0.00008131196,0.00007054597,0.0001173887,0.00008595367,0.0001405099,0.0001004136,0.00008061656,0.0002546075,0.0001185906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009621611,"about_ca_system_score_gemma":0.0001327847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00027564,"about_ca_topic_score_gemma":0.0005002822,"domain_scores_codex":[0.9999665,0.000006694694,0.000003667865,0.000005986309,0.00000813178,0.000009022797],"domain_scores_gemma":[0.9999412,0.00001519252,0.00001690525,0.000006002873,0.000005794855,0.00001479235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006558041,0.00001884362,0.00007694984,0.00001368897,0.000001040343,0.00001091103,0.000002365166,0.00001716882,0.9994281,0.000008540635,0.000003894167,0.000352996],"study_design_scores_gemma":[0.00002983408,0.0007966442,0.005006906,0.000004810034,0.000009004624,0.000106909,0.000012721,0.0003633806,0.9931409,0.00002379164,0.0005035443,0.000001588011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99791,0.0007310141,0.0008143759,0.00003094643,0.000009438982,0.000007969178,0.00009681144,0.00001428823,0.0003851358],"genre_scores_gemma":[0.9970463,0.0007404886,0.001000189,0.00003060976,0.000008805116,0.00001251017,0.0003168657,0.000004501414,0.0008397411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004406317,"threshold_uncertainty_score":0.001474023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0557591110724094,"score_gpt":0.2855236704611807,"score_spread":0.2297645593887712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}