{"id":"W2059717570","doi":"10.1007/s10875-014-9996-4","title":"Fatal Pneumococcal Meningitis in a 7-Year-Old Girl with Interleukin-1 Receptor Activated Kinase Deficiency (IRAK-4) Despite Prophylactic Antibiotic and IgG Responses to Streptococcus Pneumoniae Vaccines","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Izaak Walton Killam Health Centre; Dalhousie University","funders":"","keywords":"Medicine; Streptococcus pneumoniae; Meningitis; Immunology; Vaccination; Pneumococcal polysaccharide vaccine; Pneumococcal vaccine; Neutropenia; Antibiotics; Internal medicine; Pediatrics; Chemotherapy; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002264855,0.0003415,0.00111257,0.0006825003,0.0001421434,0.00005600361,0.0004373127,0.0005309829,0.0001072277],"category_scores_gemma":[0.004371344,0.0002532073,0.0001832856,0.000421698,0.0003973199,0.0003959937,0.0001916618,0.001336204,0.0001392092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008022273,"about_ca_system_score_gemma":0.0002545576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003997333,"about_ca_topic_score_gemma":0.00003160459,"domain_scores_codex":[0.9949336,0.002006323,0.001947134,0.0004420522,0.00009926231,0.0005716261],"domain_scores_gemma":[0.9961682,0.001901326,0.001081117,0.0004075791,0.000358514,0.00008325655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01301238,0.0003980848,0.06717557,0.00002874569,0.0002255361,0.00006550586,0.0003979113,0.000008028005,0.8917243,0.000139375,0.00005209346,0.02677242],"study_design_scores_gemma":[0.008132703,0.0160764,0.6350011,0.0005189595,0.0001383161,0.0008572959,0.0006050444,0.000008419878,0.3334219,0.00009018509,0.004670752,0.000478916],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963707,0.0007546677,0.0001339871,0.001266704,0.0009125523,0.0004370603,0.000005066511,0.00003233394,0.00008692758],"genre_scores_gemma":[0.9988323,0.000215394,0.000293888,0.00009703597,0.00009184152,0.00001022433,0.000009313212,0.00003399157,0.0004159395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5678256,"threshold_uncertainty_score":0.999992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01735561570054443,"score_gpt":0.2993316985993356,"score_spread":0.2819760828987912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}