{"id":"W2059732741","doi":"10.4161/trla.27694","title":"Internal translation initiation from HIV-1 transcripts is conferred by a common RNA structure","year":2014,"lang":"en","type":"article","venue":"Translation","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; University of Texas MD Anderson Cancer Center; National Institutes of Health; McGill University; National Institute of General Medical Sciences; Medical Research Council; American Heart Association; Howard Hughes Medical Institute","keywords":"Internal ribosome entry site; Exon; Start codon; Genetics; Eukaryotic translation; Biology; Translation (biology); RNA; RNA splicing; Ribosome; Coding region; Computational biology; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004285286,0.0004885866,0.0003864637,0.0003956947,0.0005300831,0.0008356431,0.0002472079,0.0003294889,0.0007380504],"category_scores_gemma":[0.0007268604,0.0003635527,0.0005754218,0.0002376666,0.000715588,0.0005160782,0.0009008239,0.0004950166,0.0004247328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004120751,"about_ca_system_score_gemma":0.0004261032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002291263,"about_ca_topic_score_gemma":0.0004005462,"domain_scores_codex":[0.9994599,0.00008029828,0.00003545229,0.0001538028,0.0001708701,0.00009967307],"domain_scores_gemma":[0.9994389,0.0001361693,0.000169056,0.0001216425,0.00005083743,0.0000832899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007267555,0.00001898334,0.001846152,0.00003760034,0.00000833356,0.0001916543,0.00006133591,0.0001538744,0.9929045,0.001175785,0.00002418992,0.003504925],"study_design_scores_gemma":[0.00002803456,0.0005179639,0.01724013,0.00002814584,0.00003932017,0.001535596,0.0001051061,0.002096589,0.9753347,0.001314417,0.001744143,0.0000158666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917938,0.0007421507,0.005321447,0.00003441881,0.00001134291,0.00001278528,0.00004407976,0.00008903939,0.001950905],"genre_scores_gemma":[0.9963332,0.0002263513,0.002785371,0.00002240942,0.000008841129,0.000009323366,0.0001034721,0.00001553534,0.0004953893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008356431,"threshold_uncertainty_score":0.002989829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01732077036216667,"score_gpt":0.240056310965802,"score_spread":0.2227355406036353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}