{"id":"W2059732741","doi":"10.4161/trla.27694","title":"Internal translation initiation from HIV-1 transcripts is conferred by a common RNA structure","year":2014,"lang":"en","type":"article","venue":"Translation","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; University of Texas MD Anderson Cancer Center; National Institutes of Health; McGill University; National Institute of General Medical Sciences; Medical Research Council; American Heart Association; Howard Hughes Medical Institute","keywords":"Internal ribosome entry site; Exon; Start codon; Genetics; Eukaryotic translation; Biology; Translation (biology); RNA; RNA splicing; Ribosome; Coding region; Computational biology; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001177401,0.0001783306,0.0001593638,0.00003636473,0.00007453588,0.00004245192,0.0001327828,0.0002565968,0.0002180686],"category_scores_gemma":[0.00000688201,0.0001827143,0.00009470333,0.00004946662,0.00002698486,0.00001871224,0.000003404164,0.00009050409,0.00001264769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007474704,"about_ca_system_score_gemma":0.00001571112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007853857,"about_ca_topic_score_gemma":0.0001005223,"domain_scores_codex":[0.9989273,0.0001512972,0.0002714135,0.0003142665,0.0001782949,0.0001574082],"domain_scores_gemma":[0.9995793,0.00002365477,0.00008964394,0.0002110792,0.00003656705,0.00005978266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000177106,0.00001803925,0.000229237,0.000009549454,0.00003008594,1.495218e-7,0.0004961121,0.00002079901,0.8928917,0.00004418343,0.0004027818,0.1056803],"study_design_scores_gemma":[0.0012189,0.0001426114,0.0008779228,0.00002528383,0.00004907971,0.000001655741,0.00002163284,0.002358801,0.9646797,0.002222199,0.02817015,0.000232132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.651332,0.0006455712,0.3447406,0.0007364962,0.0001758164,0.0002757345,0.0003896212,0.0000302759,0.001673884],"genre_scores_gemma":[0.994849,0.00005182292,0.002117957,0.0004312159,0.000207112,0.00001322721,0.002241364,0.00002835408,0.00006000296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3435169,"threshold_uncertainty_score":0.7450871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01732077036216667,"score_gpt":0.240056310965802,"score_spread":0.2227355406036353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}