{"id":"W2059734062","doi":"10.1002/biof.1034","title":"The hypotriglyceridemic effect of biotin supplementation involves increased levels of cGMP and AMPK activation","year":2012,"lang":"en","type":"article","venue":"BioFactors","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Tellabs (Canada)","funders":"Universidad Michoacana de San Nicolás de Hidalgo; Consejo Nacional de Ciencia y Tecnología","keywords":"Biotin; AMPK; Acetyl-CoA carboxylase; Endocrinology; Internal medicine; Sterol regulatory element-binding protein; Lipogenesis; Pyruvate carboxylase; Triglyceride; Fatty acid synthase; Chemistry; Biotin deficiency; AMP-activated protein kinase; Phosphorylation; Protein kinase A; Biochemistry; Biology; Lipid metabolism; Enzyme; Cholesterol; Sterol; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001166279,0.0003887198,0.0003693832,0.0002795178,0.0001783046,0.0002026725,0.0001467333,0.0003682939,0.001654674],"category_scores_gemma":[0.0001282406,0.0001560374,0.0002843078,0.0001105962,0.0003241613,0.0002482838,0.0002666143,0.0004348053,0.0001638811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003439901,"about_ca_system_score_gemma":0.0002382258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009538779,"about_ca_topic_score_gemma":0.001827439,"domain_scores_codex":[0.9998335,0.00002373728,0.00001543025,0.00004951818,0.00004420169,0.00003369085],"domain_scores_gemma":[0.9998574,0.00001384522,0.00004852367,0.00001309418,0.00002238835,0.00004468905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004935195,0.00001154346,0.0002271165,0.00002977873,0.000003504955,0.00002628794,0.00000939543,0.000008350318,0.9985379,0.00002482255,0.000008185139,0.0006196377],"study_design_scores_gemma":[0.00003574744,0.0004173303,0.01831224,0.00001139179,0.00002278284,0.0001519671,0.00003659866,0.0002728218,0.9796208,0.00009288404,0.001018214,0.000007351408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945086,0.002257962,0.001774184,0.0001628326,0.00003378904,0.00002390654,0.000375499,0.00006021262,0.0008031224],"genre_scores_gemma":[0.9928347,0.001176089,0.002489955,0.00009826442,0.00001613378,0.00005787905,0.0004282375,0.0000216037,0.002877157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001654674,"threshold_uncertainty_score":0.005535483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01216442285665707,"score_gpt":0.2631953196780475,"score_spread":0.2510308968213904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}