{"id":"W2059734062","doi":"10.1002/biof.1034","title":"The hypotriglyceridemic effect of biotin supplementation involves increased levels of cGMP and AMPK activation","year":2012,"lang":"en","type":"article","venue":"BioFactors","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Tellabs (Canada)","funders":"Universidad Michoacana de San Nicolás de Hidalgo; Consejo Nacional de Ciencia y Tecnología","keywords":"Biotin; AMPK; Acetyl-CoA carboxylase; Endocrinology; Internal medicine; Sterol regulatory element-binding protein; Lipogenesis; Pyruvate carboxylase; Triglyceride; Fatty acid synthase; Chemistry; Biotin deficiency; AMP-activated protein kinase; Phosphorylation; Protein kinase A; Biochemistry; Biology; Lipid metabolism; Enzyme; Cholesterol; Sterol; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002484719,0.00009051793,0.0001086816,0.00002553449,0.00006879991,0.000003983835,0.00005247855,0.000112165,0.000005935232],"category_scores_gemma":[0.0001368148,0.0000543423,0.00004289317,0.00005986821,0.0001396393,0.000004641827,0.00004793692,0.00004481435,5.066871e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006201294,"about_ca_system_score_gemma":0.00001158068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006667365,"about_ca_topic_score_gemma":0.000004851443,"domain_scores_codex":[0.9994605,0.000086163,0.0001657214,0.00009017798,0.00007211703,0.0001253224],"domain_scores_gemma":[0.9996074,0.00008839665,0.000137105,0.0001050591,0.00002982418,0.00003221866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008396302,0.00001359129,0.1752662,0.00003127187,0.00007149887,1.147978e-8,0.00007725671,2.057037e-7,0.8209638,0.0000240774,0.0002242114,0.00324392],"study_design_scores_gemma":[0.000363237,0.0001973354,0.1433787,0.00001159324,0.0000224998,5.207305e-7,0.0001438467,0.000001952709,0.8544559,0.000004409942,0.001366355,0.00005357557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983382,0.001170461,0.0000325204,0.00005648752,0.0001085062,0.0001520601,0.0000344602,0.00000385092,0.0001034602],"genre_scores_gemma":[0.9992326,0.0005613291,0.00005814444,0.00001234077,0.00005043577,0.000003533539,0.00003706596,0.000006861907,0.00003769037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03349213,"threshold_uncertainty_score":0.2216015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01216442285665707,"score_gpt":0.2631953196780475,"score_spread":0.2510308968213904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}