{"id":"W2059740732","doi":"10.1371/journal.pone.0005644","title":"HIV-1 RNA Dysregulates the Natural TLR Response to Subclinical Endotoxemia in Kenyan Female Sex-Workers","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; McMaster University; Public Health Agency of Canada; University of Manitoba","funders":"Canadian Institutes of Health Research; Ontario HIV Treatment Network; University of Manitoba; Bill and Melinda Gates Foundation","keywords":"TLR4; Peripheral blood mononuclear cell; Immunology; Proinflammatory cytokine; Immune system; Ex vivo; Subclinical infection; Viral load; Medicine; Biology; Cytokine; Pathogenesis; In vivo; Inflammation; Internal medicine; In vitro; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009624062,0.0001932375,0.0001210569,0.0001658506,0.0004274894,0.0003394728,0.0001230178,0.0002574459,0.00323161],"category_scores_gemma":[0.0003205836,0.0001692827,0.00008134724,0.00008365703,0.0001870135,0.00009293974,0.0001829508,0.000214974,0.0003854985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001114663,"about_ca_system_score_gemma":0.0001371847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001146981,"about_ca_topic_score_gemma":0.00170918,"domain_scores_codex":[0.9999411,0.00001261746,0.000002685043,0.00001226724,0.000008760666,0.00002257054],"domain_scores_gemma":[0.9998955,0.00001709065,0.0000386514,0.000005991149,0.0000178705,0.00002489983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002546766,0.0005714245,0.3668064,0.0002626043,0.00003422477,0.001760869,0.002534873,0.00005004106,0.6111371,0.0001397806,0.0007256984,0.01343023],"study_design_scores_gemma":[0.00003309697,0.001276216,0.9846033,0.00004674027,0.0000258219,0.001074733,0.001991547,0.0001562795,0.0096241,0.00006472746,0.001094889,0.000008515193],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995484,0.00013165,0.00003410353,0.00002072456,0.000004129872,0.000007329023,0.00004114769,0.000002183301,0.0002102091],"genre_scores_gemma":[0.9988804,0.0001815262,0.00008865393,0.00004963232,0.000008566047,0.00002270029,0.00008385944,0.000002183026,0.0006823807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00323161,"threshold_uncertainty_score":0.01081085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02183794332630182,"score_gpt":0.2485086475496474,"score_spread":0.2266707042233455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}