{"id":"W2059740732","doi":"10.1371/journal.pone.0005644","title":"HIV-1 RNA Dysregulates the Natural TLR Response to Subclinical Endotoxemia in Kenyan Female Sex-Workers","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; McMaster University; Public Health Agency of Canada; University of Manitoba","funders":"Canadian Institutes of Health Research; Ontario HIV Treatment Network; University of Manitoba; Bill and Melinda Gates Foundation","keywords":"TLR4; Peripheral blood mononuclear cell; Immunology; Proinflammatory cytokine; Immune system; Ex vivo; Subclinical infection; Viral load; Medicine; Biology; Cytokine; Pathogenesis; In vivo; Inflammation; Internal medicine; In vitro; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001060655,0.0001741151,0.0003200294,0.0001571158,0.000160031,0.00002454271,0.0003329269,0.000236879,0.0001970391],"category_scores_gemma":[0.000822121,0.0001298595,0.0000861887,0.0002484389,0.0001107722,0.0001071249,0.00006468913,0.0005414907,0.001338563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007233295,"about_ca_system_score_gemma":0.00007585059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002058123,"about_ca_topic_score_gemma":0.00001233678,"domain_scores_codex":[0.9980085,0.0007854952,0.0004391248,0.0002721765,0.00007356172,0.000421064],"domain_scores_gemma":[0.9985723,0.000814631,0.00008874891,0.0004481123,0.00005102071,0.00002520422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006428006,0.0003781844,0.004171694,0.000005273581,0.0001128262,0.00001188638,0.001055187,0.00000871606,0.9845067,0.00009125838,0.001052529,0.002177773],"study_design_scores_gemma":[0.001392871,0.0004047899,0.1878838,0.0001382354,0.00004234832,0.00001204205,0.0003240378,0.00002157096,0.8058097,0.00008810582,0.003678075,0.0002044634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879019,0.001064226,0.00000420785,0.009823785,0.0001317173,0.0004593086,0.000003530886,0.00007356698,0.0005377245],"genre_scores_gemma":[0.9865446,0.00003664912,0.000122878,0.0008263154,0.0000507965,0.00002765921,0.00004201881,0.00001280502,0.01233628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1837121,"threshold_uncertainty_score":0.999439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02183794332630182,"score_gpt":0.2485086475496474,"score_spread":0.2266707042233455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}