{"id":"W2059812027","doi":"10.1074/jbc.m114.618496","title":"Scaffold Protein JLP Is Critical for CD40 Signaling in B Lymphocytes","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Internalization; Cell biology; CD154; CD40; Biology; MAPK/ERK pathway; Signal transduction; Signal transducing adaptor protein; Scaffold protein; Receptor; Biochemistry; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001149326,0.000416846,0.0002045481,0.0002301422,0.0004581192,0.0004600517,0.0002357008,0.0004280425,0.001937109],"category_scores_gemma":[0.0001845951,0.0001593921,0.0002916566,0.0001432207,0.0002727911,0.0002999487,0.0005413675,0.0005773371,0.001090287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005009607,"about_ca_system_score_gemma":0.0003225921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004611427,"about_ca_topic_score_gemma":0.0003647288,"domain_scores_codex":[0.999813,0.00002246049,0.00001930135,0.00004199014,0.00005393411,0.00004920301],"domain_scores_gemma":[0.9997784,0.00001606199,0.00007781581,0.00001530862,0.00002932147,0.00008298696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008364273,0.000009925949,0.0003197532,0.00004541522,0.000003339117,0.0002377564,0.00001416127,0.00003230381,0.9983525,0.0001244716,0.00005976012,0.0007169716],"study_design_scores_gemma":[0.00004130079,0.0001413234,0.02083364,0.00002663672,0.00003743797,0.002100022,0.0001036778,0.00123289,0.9670269,0.0002626984,0.008180798,0.00001256591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991154,0.002901467,0.003804771,0.0001902822,0.00005075128,0.00001823119,0.0004555096,0.0002099964,0.001214857],"genre_scores_gemma":[0.9960288,0.0005869556,0.001221323,0.00004576812,0.00001629863,0.00002196045,0.0006289337,0.00003352052,0.001416567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001937109,"threshold_uncertainty_score":0.006480336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04280807154360395,"score_gpt":0.2867446657565537,"score_spread":0.2439365942129498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}