{"id":"W2059929422","doi":"10.1038/srep00894","title":"Architecture of the HCN selectivity filter and control of cation permeation","year":2012,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Michael Smith Health Research BC; Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Selectivity; Potassium channel; Chemistry; Cysteine; Biophysics; Voltage-gated potassium channel; Threonine; Permeation; Binding site; Potassium; Serine; Biochemistry; Biology; Phosphorylation; Membrane; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001010356,0.0001077566,0.0001698418,0.0001368812,0.0002213415,0.0003910122,0.0002363011,0.0003064832,0.0004386364],"category_scores_gemma":[0.0001465652,0.0001055259,0.0001624178,0.00008261414,0.0003125669,0.0003739264,0.0001874493,0.0002339435,0.0002801228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004912407,"about_ca_system_score_gemma":0.0003632182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001234678,"about_ca_topic_score_gemma":0.0009827178,"domain_scores_codex":[0.9999149,0.000007307175,0.000003998834,0.00002774704,0.00001987296,0.00002609065],"domain_scores_gemma":[0.9998883,0.00001426452,0.00003087422,0.00001213266,0.00001779705,0.00003662945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006735409,0.000004049176,0.0006346271,0.00001371589,0.000002307567,0.00007015676,0.00002303024,0.000210941,0.9962164,0.001307712,0.00002845556,0.001421382],"study_design_scores_gemma":[0.00002986387,0.0001425314,0.03580239,0.00001047958,0.00001635664,0.0009180478,0.00008871609,0.01416686,0.9414008,0.001835853,0.005561584,0.00002644337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889886,0.0004896853,0.008787462,0.00006568046,0.00001080778,0.000007862102,0.00006009185,0.00008305378,0.001506661],"genre_scores_gemma":[0.9947319,0.000230367,0.00406144,0.00003546196,0.000009215451,0.000006400089,0.00008421737,0.00001247374,0.0008285092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001234678,"threshold_uncertainty_score":0.003564239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007693501868794091,"score_gpt":0.2174149541101644,"score_spread":0.2097214522413703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}