{"id":"W2059939522","doi":"10.1186/ar3964","title":"Dysregulation of the serine/threonine phosphatase PP2A contributes to autoimmunity","year":2012,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Canadian Arthritis Network; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Arthritis Society; Lupus Research Alliance; Arthritis Foundation","keywords":"Protein phosphatase 2; Immune system; Immunology; Autoimmunity; Lupus nephritis; Glomerulonephritis; Biology; Immune dysregulation; FOXP3; Phosphatase; Endocrinology; Internal medicine; Medicine; Cell biology; Kidney; Phosphorylation; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001571373,0.0001711601,0.0003213581,0.000131077,0.0007034248,0.00002717935,0.0005894023,0.0002250783,0.001396555],"category_scores_gemma":[0.000216904,0.0001233058,0.0001133926,0.0005957181,0.001038318,0.0001683557,0.0003128315,0.0006118306,0.0006560623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005636693,"about_ca_system_score_gemma":0.0001128967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008081437,"about_ca_topic_score_gemma":0.0001149435,"domain_scores_codex":[0.9973581,0.001065073,0.0003616254,0.0002198658,0.0001197474,0.0008756308],"domain_scores_gemma":[0.9984068,0.000382633,0.00008477202,0.0007568349,0.0003229823,0.00004602589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004046625,0.0004061587,0.01002483,0.000004917726,0.0001360151,0.000001008133,0.0006504361,0.000003665351,0.8914768,0.005589134,0.007378625,0.08392373],"study_design_scores_gemma":[0.001946507,0.0002965918,0.04402415,0.0000457442,0.000002839834,0.0000192898,0.0001487283,0.000001395281,0.6135727,0.0005053411,0.339336,0.0001006755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9142303,0.08144649,0.00003435014,0.002266355,0.0007359083,0.0007015936,0.00007301752,0.00004740346,0.0004646248],"genre_scores_gemma":[0.9940189,0.003142762,0.00005321455,0.0002619091,0.00003724325,0.00009208959,0.00008863606,0.0000212215,0.002284066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3319574,"threshold_uncertainty_score":0.9995163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03493417959709986,"score_gpt":0.3059211735971714,"score_spread":0.2709869940000715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}