{"id":"W2059980335","doi":"10.1038/sj.cdd.4402154","title":"Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response","year":2007,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"School of Medicine, New York University; Nagoya City University; York University; Ministry of Education, Culture, Sports, Science and Technology; Kanazawa University","keywords":"XBP1; Unfolded protein response; ATF6; Endoplasmic reticulum; Kinase; Cell biology; Apoptosis; Chemistry; Protein kinase A; ATF4; ASK1; Phosphorylation; Signal transduction; Protein kinase R; Molecular biology; Biology; Mitogen-activated protein kinase kinase; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001679043,0.00009131552,0.0001104337,0.00005692059,0.00004651996,0.000006922633,0.00003698799,0.00009728572,0.00002016556],"category_scores_gemma":[0.00007750736,0.0000839065,0.00005943681,0.00005760905,0.00002748835,0.000004403902,0.00002396552,0.00003126983,4.191385e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008533218,"about_ca_system_score_gemma":0.00003454152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002027888,"about_ca_topic_score_gemma":0.000005864461,"domain_scores_codex":[0.9992838,0.00005603386,0.0002470507,0.0001745529,0.0001212783,0.0001172801],"domain_scores_gemma":[0.9995123,0.00002755876,0.0001675013,0.0001209241,0.00009102926,0.00008073923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001820479,0.00009874717,0.0206114,0.00005424325,0.00001363198,1.735309e-7,0.00001942875,0.000009971393,0.9765639,0.00005379679,0.00001039721,0.0007438089],"study_design_scores_gemma":[0.0004451684,0.0001589089,0.2542143,0.0000152196,0.00002485697,4.806516e-7,0.00001467643,0.0001812286,0.7447202,0.000143591,0.00001593356,0.00006543646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895853,0.00009831593,0.009940578,0.000008334084,0.00004792665,0.0001640018,0.00001241852,0.000005726165,0.0001373412],"genre_scores_gemma":[0.9993384,0.000006991666,0.0003172693,0.000005035027,0.0000443844,0.000006931023,0.000179437,0.000007916778,0.00009360462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2336029,"threshold_uncertainty_score":0.3421608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009426795533274811,"score_gpt":0.2315667489461702,"score_spread":0.2221399534128954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}