{"id":"W2060021617","doi":"10.1074/jbc.m402828200","title":"Activation of Peroxisome Proliferator-activated Receptor γ Inhibits Interleukin-1β-induced Membrane-associated Prostaglandin E2 Synthase-1 Expression in Human Synovial Fibroblasts by Interfering with Egr-1","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame; Hôpital Maisonneuve-Rosemont; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Peroxisome proliferator-activated receptor; Troglitazone; Thiazolidinedione; Electrophoretic mobility shift assay; Receptor; Chemistry; Molecular biology; Prostaglandin E2; Transcription factor; Small interfering RNA; Cell biology; Biology; Endocrinology; Biochemistry; Transfection; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000383469,0.0004260333,0.0006505796,0.0001098652,0.00008403451,0.00004000799,0.0003689495,0.0007436032,0.00006647441],"category_scores_gemma":[0.000518919,0.0003087379,0.0001645455,0.000321928,0.000163334,0.00005313322,0.0001492309,0.0007265987,9.063681e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003299344,"about_ca_system_score_gemma":0.0002167076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001035284,"about_ca_topic_score_gemma":0.000002531964,"domain_scores_codex":[0.997607,0.0001440793,0.0009718561,0.0004871735,0.0003513509,0.0004385644],"domain_scores_gemma":[0.998198,0.00004039381,0.001015248,0.0002182185,0.0003178104,0.000210354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002264739,0.0007599184,0.004948318,0.00008883488,0.0001246174,0.000008823773,0.0001086637,0.00008544273,0.9914514,5.944141e-7,0.00006532633,0.00009326646],"study_design_scores_gemma":[0.003422763,0.002171301,0.0002995931,0.001071567,0.00001160914,0.00005377699,0.0002174244,0.000002022094,0.9922981,0.00001123007,0.00007182481,0.000368733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992681,0.00007892543,0.0001002853,0.00008265232,0.00006755139,0.0002824368,0.00003560271,0.00002312269,0.000061338],"genre_scores_gemma":[0.9992751,0.00004249832,0.0001895523,0.00003640781,0.0001828773,0.00002518292,0.0001779228,0.00004342857,0.00002705893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004648725,"threshold_uncertainty_score":0.9999365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01316387952228205,"score_gpt":0.2423847484542893,"score_spread":0.2292208689320072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}