{"id":"W2060021617","doi":"10.1074/jbc.m402828200","title":"Activation of Peroxisome Proliferator-activated Receptor γ Inhibits Interleukin-1β-induced Membrane-associated Prostaglandin E2 Synthase-1 Expression in Human Synovial Fibroblasts by Interfering with Egr-1","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame; Hôpital Maisonneuve-Rosemont; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Peroxisome proliferator-activated receptor; Troglitazone; Thiazolidinedione; Electrophoretic mobility shift assay; Receptor; Chemistry; Molecular biology; Prostaglandin E2; Transcription factor; Small interfering RNA; Cell biology; Biology; Endocrinology; Biochemistry; Transfection; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000199114,0.0005128283,0.0006045875,0.0002184444,0.0001512557,0.0003733998,0.0002391701,0.0002460261,0.001309293],"category_scores_gemma":[0.0001173541,0.0001975629,0.0004188737,0.0002434995,0.0002665897,0.0001486646,0.0002142002,0.0007250285,0.000578073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001897549,"about_ca_system_score_gemma":0.0003941339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007894563,"about_ca_topic_score_gemma":0.001095103,"domain_scores_codex":[0.9997513,0.00004525758,0.00003734813,0.00004070645,0.00004536496,0.00008010619],"domain_scores_gemma":[0.9999533,0.000008025379,0.00001250424,0.000008496658,0.000005217569,0.00001248902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007023106,0.0002402932,0.0001863807,0.0001306693,0.00002551248,0.00010022,0.00005347801,0.0001631081,0.9944924,0.0001105546,0.0001865142,0.003608665],"study_design_scores_gemma":[0.0003797277,0.002444667,0.004303575,0.00002431693,0.00009558912,0.0004034357,0.000108169,0.001832132,0.9826811,0.00008149423,0.007633625,0.00001207259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912255,0.003982986,0.001769392,0.0002123135,0.0000990085,0.00007319383,0.0003970203,0.0001046421,0.002135953],"genre_scores_gemma":[0.9887801,0.004457996,0.002043014,0.0001729392,0.0000320414,0.0001612836,0.0009513317,0.0000197746,0.00338154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001309293,"threshold_uncertainty_score":0.004380047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01316387952228205,"score_gpt":0.2423847484542893,"score_spread":0.2292208689320072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}