{"id":"W2060042016","doi":"10.4161/23723556.2014.975633","title":"PTP1B: mediating ROS signaling to silence genes","year":2015,"lang":"en","type":"article","venue":"Molecular & Cellular Oncology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"Senescence; Reactive oxygen species; Biology; Cell biology; Protein tyrosine phosphatase; Gene; Phosphatase; Signal transduction; Genetics; Phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003474097,0.0003173926,0.0002288704,0.0001923283,0.0002656309,0.0004688098,0.0003056664,0.0003616188,0.002429823],"category_scores_gemma":[0.0001814953,0.0001590074,0.0001785852,0.0001383898,0.0002754203,0.000279425,0.0004518644,0.0008550558,0.0007619562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00031044,"about_ca_system_score_gemma":0.0002274485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003541645,"about_ca_topic_score_gemma":0.0005647326,"domain_scores_codex":[0.9997906,0.00002741723,0.000009797923,0.00005751495,0.00006642228,0.00004826866],"domain_scores_gemma":[0.9999225,0.00001366186,0.00001948164,0.000010432,0.000008904224,0.00002498847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005249682,0.00001751802,0.0001112158,0.00005291658,0.000004483382,0.000059499,0.00001963049,0.00009103932,0.9953885,0.0009091482,0.0001959144,0.003097603],"study_design_scores_gemma":[0.0000256952,0.000152822,0.0008513819,0.000007348934,0.00001156055,0.0003058304,0.00001590426,0.00167453,0.9856953,0.0002968521,0.01095797,0.000004769413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9008388,0.0129623,0.06911745,0.001576461,0.0004546244,0.0001871709,0.0009521102,0.001240792,0.01267033],"genre_scores_gemma":[0.9814032,0.00261746,0.009047712,0.0001623691,0.00004842016,0.00009978928,0.0004028167,0.00008576504,0.006132397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002429823,"threshold_uncertainty_score":0.008128524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02157387441753408,"score_gpt":0.2849301481691584,"score_spread":0.2633562737516243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}