{"id":"W2060066452","doi":"10.1093/jnci/dju252","title":"Obesity and Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus: A Mendelian Randomization Study","year":2014,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Princess Margaret Cancer Centre; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; U.S. Public Health Service","keywords":"Mendelian randomization; Medicine; Confounding; Body mass index; Odds ratio; Internal medicine; Barrett's esophagus; Confidence interval; Obesity; Population; Propensity score matching; Adenocarcinoma; Cancer; Genetics; Biology; Genetic variants; Genotype; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00966865,0.0007655384,0.0008702132,0.0009802454,0.0004757216,0.0006711521,0.0007784238,0.001047298,0.001804973],"category_scores_gemma":[0.03009812,0.0005546047,0.001403673,0.001241724,0.0007677258,0.0003885199,0.0004659318,0.0006062305,0.0002072004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004508854,"about_ca_system_score_gemma":0.0006397832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003650587,"about_ca_topic_score_gemma":0.00149619,"domain_scores_codex":[0.9894221,0.00820284,0.0003748254,0.001148911,0.0006127069,0.0002384817],"domain_scores_gemma":[0.9895715,0.005737077,0.001886873,0.002169978,0.000304597,0.0003300972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01577681,0.0006562156,0.9409305,0.0001442348,0.007197279,0.001449628,0.000381577,0.003984835,0.002481965,0.005116796,0.001190122,0.02069009],"study_design_scores_gemma":[0.01214018,0.00778436,0.7978185,0.0001954363,0.01081214,0.009513913,0.0003175408,0.1385964,0.001888745,0.01634095,0.004366938,0.0002249216],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796713,0.001016184,0.01764692,0.0003826539,0.00005853745,0.0002346199,0.0003275773,0.00008049982,0.0005816572],"genre_scores_gemma":[0.9937013,0.0002027587,0.005453299,0.0001027425,0.00002998416,0.000118127,0.0001680115,0.00001452083,0.0002091646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00966865,"threshold_uncertainty_score":0.05113333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0274459352669462,"score_gpt":0.325468880984811,"score_spread":0.2980229457178648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}