{"id":"W2060066452","doi":"10.1093/jnci/dju252","title":"Obesity and Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus: A Mendelian Randomization Study","year":2014,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Princess Margaret Cancer Centre; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; U.S. Public Health Service","keywords":"Mendelian randomization; Medicine; Confounding; Body mass index; Odds ratio; Internal medicine; Barrett's esophagus; Confidence interval; Obesity; Population; Propensity score matching; Adenocarcinoma; Cancer; Genetics; Biology; Genetic variants; Genotype; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001007367,0.0001214909,0.0003539857,0.0001584436,0.000156301,0.00002101678,0.0001128555,0.00004287482,0.00002557787],"category_scores_gemma":[0.0005685952,0.00007375196,0.00009773282,0.0001907571,0.0001578286,0.0002102139,0.00005938543,0.0002612239,5.634256e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002215466,"about_ca_system_score_gemma":0.0004254147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002727085,"about_ca_topic_score_gemma":0.0001883831,"domain_scores_codex":[0.9982395,0.0001789736,0.0003990036,0.0001413755,0.00091738,0.0001237923],"domain_scores_gemma":[0.9985982,0.0001116182,0.0004040983,0.00009737186,0.000629419,0.0001592849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001607306,0.0002279518,0.9939549,0.00005715164,0.0004890764,0.00001716046,0.0003891803,0.0003374056,0.00002756314,0.0002797679,0.0003166602,0.002295907],"study_design_scores_gemma":[0.01439749,0.0007199505,0.9816306,0.00009780151,0.0004488167,0.0001421478,0.00004657186,0.0004993408,0.001108324,0.0007781406,0.00007496827,0.00005584247],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975208,0.02284359,0.0001500609,0.0007901085,0.0003542165,0.0005181502,0.0000391033,0.000004537751,0.00009220875],"genre_scores_gemma":[0.9982018,0.0007979405,0.000271457,0.0001446519,0.0004732991,0.00001409581,0.000001664246,0.00000849725,0.00008655833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02299381,"threshold_uncertainty_score":0.3007517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0274459352669462,"score_gpt":0.325468880984811,"score_spread":0.2980229457178648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}