{"id":"W2060086419","doi":"10.1083/jcb.201004005","title":"Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes","year":2010,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Phagosome; Cell biology; Pseudopodia; Biology; Actin; Vacuole; Actin cytoskeleton; Microfilament; Pi; Phosphoinositide 3-kinase; Cytoskeleton; PI3K/AKT/mTOR pathway; Signal transduction; Biochemistry; Phagocytosis; Cytoplasm; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003174558,0.0001204149,0.000181424,0.00003647978,0.00009964049,0.00001259779,0.0001631642,0.0001823547,0.00001622731],"category_scores_gemma":[0.00003198879,0.00007797869,0.00008904301,0.00003514007,0.0001595364,0.00000777892,0.00002468747,0.0001466383,6.320885e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004472549,"about_ca_system_score_gemma":0.00005463748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009336355,"about_ca_topic_score_gemma":0.0000420782,"domain_scores_codex":[0.9993507,0.00006541254,0.0002351961,0.000122678,0.00005846348,0.000167534],"domain_scores_gemma":[0.9992664,0.00004355648,0.0003728062,0.000150833,0.0001089811,0.00005740286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006343627,0.00003217736,0.002202408,0.00001490852,0.00003258664,0.000001488376,0.00006823595,0.000002694786,0.9958043,0.00007205371,0.00004901846,0.00108577],"study_design_scores_gemma":[0.0009289924,0.0004889527,0.001215096,0.00000885213,0.00006851575,0.00006344909,0.0001592008,0.00003067699,0.9702247,0.0001787281,0.02653114,0.0001016982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922101,0.001453377,0.00504315,0.0004827098,0.0003702016,0.0001752321,0.00001536745,0.000003768661,0.0002460353],"genre_scores_gemma":[0.9978766,0.0009624662,0.0001676016,0.0001758383,0.0003333275,0.000003478623,0.0001955715,0.00001442317,0.0002706768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02648212,"threshold_uncertainty_score":0.3179879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164701627085064,"score_gpt":0.2335020775064872,"score_spread":0.2218550612356366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}