{"id":"W2060121266","doi":"10.1128/mcb.25.19.8430-8443.2005","title":"Role of Dot1-Dependent Histone H3 Methylation in G<sub>1</sub> and S Phase DNA Damage Checkpoint Functions of Rad9","year":2005,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":290,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Leukemia and Lymphoma Society; Canadian Institutes of Health Research; National Institutes of Health; University of Chicago; National Institute of General Medical Sciences; American Heart Association","keywords":"G2-M DNA damage checkpoint; Biology; Histone H3; CHEK1; Histone methyltransferase; Histone methylation; DNA damage; Molecular biology; Cell cycle checkpoint; Histone H2A; Histone; Histone code; Cell biology; Genetics; DNA methylation; Cell cycle; DNA; Gene; Nucleosome; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006309079,0.0003628525,0.0001939863,0.0001376063,0.0001384718,0.0002765681,0.0002213531,0.0002534078,0.001128347],"category_scores_gemma":[0.00007038785,0.0001575453,0.0001461968,0.00008182806,0.0001584235,0.0001449317,0.0002472904,0.000235999,0.0004917966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003086957,"about_ca_system_score_gemma":0.0001501559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007354169,"about_ca_topic_score_gemma":0.001256725,"domain_scores_codex":[0.9999396,0.000005681755,0.000005897046,0.00001797267,0.00001776461,0.00001317806],"domain_scores_gemma":[0.999922,0.000009420538,0.00002675642,0.000009233272,0.000008411545,0.00002416195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005809954,0.0000070086,0.000518701,0.00001391334,0.000002044105,0.0000340412,0.000005885859,0.00005714083,0.9987776,0.00003714574,0.000008063111,0.0004803321],"study_design_scores_gemma":[0.000005654963,0.00005893079,0.01289013,0.000002741188,0.000006940735,0.0002208463,0.0000138825,0.0006014092,0.9855189,0.00002546922,0.0006518399,0.000003157744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979166,0.0005209814,0.0006651257,0.0000321753,0.000003741385,0.000006723603,0.0002398763,0.00003942853,0.0005753107],"genre_scores_gemma":[0.9975006,0.0002032232,0.0006003801,0.0000182456,0.000001247984,0.000006946042,0.0004785402,0.00001384596,0.001177115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001128347,"threshold_uncertainty_score":0.003774703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005158950683886239,"score_gpt":0.233875599914816,"score_spread":0.2287166492309298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}