{"id":"W2060136890","doi":"10.1016/j.yexcr.2010.07.004","title":"High levels of glucose induce apoptosis in cardiomyocyte via epigenetic regulation of the insulin-like growth factor receptor","year":2010,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; National Institutes of Natural Sciences; Macdonald Stewart Foundation; American Heart Association; National Natural Science Foundation of China; National Heart, Lung, and Blood Institute; U.S. Department of Defense","keywords":"Biology; Psychological repression; Diabetic cardiomyopathy; Histone; Gene silencing; Histone deacetylase; HDAC1; Acetylation; Epigenetics; Insulin-like growth factor; Apoptosis; Receptor; Endocrinology; Internal medicine; Chromatin; Transcription factor; Growth factor; Molecular biology; Cell biology; Gene expression; Biochemistry; Cardiomyopathy; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009238157,0.0001920285,0.0001624422,0.0002220525,0.0001314669,0.0002952472,0.0001340573,0.0001468188,0.001350683],"category_scores_gemma":[0.0001121782,0.0001389165,0.0002519697,0.0001502218,0.0002082235,0.0001639151,0.0002107661,0.0005307151,0.000208951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002526327,"about_ca_system_score_gemma":0.0001140677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003278424,"about_ca_topic_score_gemma":0.0007948319,"domain_scores_codex":[0.9998882,0.00001718619,0.000007891046,0.00002084294,0.00002133942,0.00004460301],"domain_scores_gemma":[0.9999294,0.00001182431,0.00002226039,0.00001492123,0.000007172277,0.00001443155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005867973,0.00006014288,0.001363966,0.00002066517,0.00002142573,0.0001222509,0.00002522285,0.00005342275,0.9948128,0.0002526622,0.0001046622,0.002575867],"study_design_scores_gemma":[0.00009346757,0.0007126507,0.0700414,0.00001315865,0.00008433284,0.0003698597,0.0002231577,0.0008610041,0.9251179,0.0004097497,0.002059372,0.00001393822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952875,0.001365327,0.001456888,0.0002043132,0.0000852281,0.000007956442,0.0001612465,0.00004202873,0.001389525],"genre_scores_gemma":[0.9979089,0.0005682213,0.0002843667,0.00007561919,0.00001412414,0.00001245289,0.000125915,0.00001074764,0.0009996395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001350683,"threshold_uncertainty_score":0.004518449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02901022761130336,"score_gpt":0.3092111659678139,"score_spread":0.2802009383565106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}