{"id":"W2060168918","doi":"10.1074/jbc.m110.199604","title":"Intensity of Deoxycytidine Deamination of HIV-1 Proviral DNA by the Retroviral Restriction Factor APOBEC3G Is Mediated by the Noncatalytic Domain","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Center for Research Resources; Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation; National Institutes of Health; University of Saskatchewan","keywords":"APOBEC3G; Deamination; Cytidine deaminase; Processivity; Mutagenesis; Mutant; Activation-induced (cytidine) deaminase; DNA; Biology; DNA replication; Chemistry; Molecular biology; Biochemistry; Genetics; Somatic hypermutation; Gene; Enzyme; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001446133,0.0002599799,0.0001937914,0.0001971491,0.0001078768,0.0002887325,0.0002346127,0.000383374,0.002426819],"category_scores_gemma":[0.0002158465,0.0001395695,0.0001716692,0.000218982,0.0002313284,0.0001544658,0.0001673448,0.000602531,0.0003128478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004230459,"about_ca_system_score_gemma":0.0001489401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009788,"about_ca_topic_score_gemma":0.0007601108,"domain_scores_codex":[0.9996321,0.00005723796,0.0000218566,0.00007769995,0.0001578008,0.00005335403],"domain_scores_gemma":[0.9998258,0.00003540441,0.00003226216,0.00002474355,0.00003741399,0.00004442296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000916541,0.00001769108,0.0004760236,0.00001524277,0.000005147946,0.00001418556,0.000007944617,0.00002922351,0.9981968,0.0000568534,0.00001590921,0.001073353],"study_design_scores_gemma":[0.000005165439,0.0001168165,0.009204428,0.000002573793,0.000005677217,0.0001348646,0.00001510322,0.0008353827,0.9892254,0.00003950474,0.0004121599,0.000002802488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942299,0.0009021095,0.002738407,0.00004988319,0.00002062532,0.00001352052,0.0003262741,0.00005522956,0.001663997],"genre_scores_gemma":[0.9964224,0.0002079019,0.001194078,0.00002054026,0.000003090983,0.00001617667,0.0004227229,0.00001021058,0.00170299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002426819,"threshold_uncertainty_score":0.00811857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02597532434322159,"score_gpt":0.2408199970290835,"score_spread":0.214844672685862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}