{"id":"W2060206081","doi":"10.1016/s0968-0896(01)00102-x","title":"Synthesis and Biological Activity of a Photoaffinity Etoposide Probe","year":2001,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Cancer Institute","keywords":"Etoposide; Topoisomerase; Chemistry; Chinese hamster ovary cell; DNA; Stereochemistry; Biological activity; Podophyllotoxin; Cleavage (geology); Enzyme; Biochemistry; In vitro; Biology; Chemotherapy; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002564403,0.0003659992,0.0002580354,0.0002647356,0.0004220574,0.0003206389,0.0004755911,0.0006464691,0.002972903],"category_scores_gemma":[0.0002788268,0.0002598007,0.0001829122,0.0002476186,0.0003068115,0.0003726265,0.0003472061,0.0008669089,0.0008479878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000558242,"about_ca_system_score_gemma":0.0004616714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007759868,"about_ca_topic_score_gemma":0.001228404,"domain_scores_codex":[0.9998507,0.00002807761,0.000008635619,0.00003612492,0.00003288365,0.000043565],"domain_scores_gemma":[0.9998636,0.00005258228,0.00001826522,0.00002248508,0.00001349684,0.00002952892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002086389,0.00004573429,0.00008154054,0.00005466323,0.000005648463,0.0001286163,0.0000461426,0.0003186531,0.9946645,0.001132118,0.0001585947,0.003154997],"study_design_scores_gemma":[0.00001548291,0.0001337368,0.0001617587,0.000002217147,0.00000488102,0.0001034959,0.000008736939,0.00022,0.9975669,0.00006511925,0.001713283,0.000004334323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9442436,0.002400519,0.03870124,0.0007903305,0.0001146798,0.0002211121,0.0006042348,0.0003164643,0.0126078],"genre_scores_gemma":[0.9756015,0.001566877,0.01190615,0.0002042258,0.00002874843,0.0001028472,0.0008884887,0.0000442169,0.009657063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002972903,"threshold_uncertainty_score":0.009945333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02175818340285214,"score_gpt":0.253278538759598,"score_spread":0.2315203553567459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}