{"id":"W2060234934","doi":"10.1016/s1097-2765(00)00104-0","title":"Competitive Recruitment of CBP and Rb-HDAC Regulates UBF Acetylation and Ribosomal Transcription","year":2000,"lang":"en","type":"article","venue":"Molecular Cell","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"National Institute of General Medical Sciences","keywords":"Biology; Acetylation; Transcription (linguistics); Molecular biology; Chromatin remodeling; RNA polymerase II; Transcription factor; Acetyltransferase; Cell biology; P300-CBP Transcription Factors; Histone acetyltransferase; Chromatin; Promoter; DNA; Gene expression; Biochemistry; Histone Acetyltransferases; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006434099,0.0003872446,0.0007926675,0.0005170041,0.0007681363,0.001402531,0.00102204,0.0004940105,0.004657021],"category_scores_gemma":[0.0008676151,0.0006709743,0.0004962627,0.0003889426,0.0006408035,0.0007029923,0.001142054,0.0009468704,0.001745798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002123516,"about_ca_system_score_gemma":0.001053385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003904525,"about_ca_topic_score_gemma":0.0151094,"domain_scores_codex":[0.9992056,0.0000746554,0.00004739524,0.0001747653,0.0001846622,0.0003129402],"domain_scores_gemma":[0.9994975,0.000115955,0.0000510356,0.00008156119,0.00007818525,0.0001757887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006540589,0.00005194899,0.0009686223,0.00005018985,0.00001938715,0.00008039152,0.00002578764,0.0001588865,0.9922421,0.001562245,0.0003445899,0.003841776],"study_design_scores_gemma":[0.0001057958,0.0001484806,0.0151092,0.000009278898,0.00002346906,0.0003610329,0.0001446028,0.004023501,0.9751492,0.0007217927,0.004182018,0.00002167319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791854,0.006690888,0.005147021,0.0005745129,0.0001402194,0.00003754523,0.000429769,0.0002712599,0.007523327],"genre_scores_gemma":[0.9946377,0.0004230809,0.001789092,0.0000767155,0.0000288525,0.00002565035,0.0003263923,0.00007685933,0.002615611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004657021,"threshold_uncertainty_score":0.01557934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01180959448064656,"score_gpt":0.2316888807320603,"score_spread":0.2198792862514138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}