{"id":"W2060237924","doi":"10.1371/journal.pone.0035376","title":"Structural Basis of the Chromodomain of Cbx3 Bound to Methylated Peptides from Histone H1 and G9a","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Argonne National Laboratory; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; National Natural Science Foundation of China; Stiftelsen för Strategisk Forskning; Chinese Academy of Sciences; Ontario Genomics Institute; Ontario Genomics; Genome Canada; Ministry of Science and Technology of the People's Republic of China; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust","keywords":"Chromodomain; Heterochromatin protein 1; Histone; Biology; Histone H3; Heterochromatin; Non-histone protein; Genetics; Histone methylation; Chromatin; Histone methyltransferase; Histone H1; Histone H2A; Gene expression; Gene; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008542136,0.00009076943,0.0001741841,0.00001712405,0.00003766609,0.000005271227,0.0001393985,0.00007683429,0.00002231834],"category_scores_gemma":[0.00005774524,0.00007170599,0.00004540027,0.00005150586,0.00008518524,0.000002463076,0.0001508103,0.00004233727,0.000001007054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001326763,"about_ca_system_score_gemma":0.00001988706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001406957,"about_ca_topic_score_gemma":0.00006029134,"domain_scores_codex":[0.9994184,0.0000355228,0.0001740841,0.000127044,0.0001092789,0.0001356452],"domain_scores_gemma":[0.9994816,0.00001396764,0.0001035268,0.0002896514,0.00005189605,0.00005934952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002145081,0.00008890946,0.01354225,0.00002970046,0.0001697463,6.110866e-8,0.0002188574,0.000007245346,0.9856886,0.00003847306,0.00003253532,0.0001621796],"study_design_scores_gemma":[0.0002205394,0.00008230167,0.08501036,0.00002582871,0.0000921691,8.274311e-7,0.00005889377,0.000158877,0.9140179,0.0002038675,0.00003666743,0.00009182952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984909,0.0009929152,0.00001959928,0.00008125888,0.00003530734,0.0001279994,0.0001119012,0.000002481373,0.0001376921],"genre_scores_gemma":[0.995819,0.00004528476,0.003839769,0.0000507015,0.00006379563,0.00000398295,0.00003811713,0.00001355121,0.000125779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07167076,"threshold_uncertainty_score":0.2924085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01691346936024469,"score_gpt":0.2225099325784188,"score_spread":0.2055964632181741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}