{"id":"W2060237924","doi":"10.1371/journal.pone.0035376","title":"Structural Basis of the Chromodomain of Cbx3 Bound to Methylated Peptides from Histone H1 and G9a","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Argonne National Laboratory; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; National Natural Science Foundation of China; Stiftelsen för Strategisk Forskning; Chinese Academy of Sciences; Ontario Genomics Institute; Ontario Genomics; Genome Canada; Ministry of Science and Technology of the People's Republic of China; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust","keywords":"Chromodomain; Heterochromatin protein 1; Histone; Biology; Histone H3; Heterochromatin; Non-histone protein; Genetics; Histone methylation; Chromatin; Histone methyltransferase; Histone H1; Histone H2A; Gene expression; Gene; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007260819,0.0002989441,0.0002130721,0.0001166995,0.0003936238,0.000267694,0.0005920547,0.0003028241,0.004237819],"category_scores_gemma":[0.0001396445,0.0001040995,0.0003244943,0.0001311005,0.0002797305,0.0001464871,0.0002522204,0.0005992808,0.0003452326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009524236,"about_ca_system_score_gemma":0.0003800651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005204559,"about_ca_topic_score_gemma":0.004181918,"domain_scores_codex":[0.9999257,0.000004626926,0.000002240093,0.00002353023,0.00002556883,0.0000181976],"domain_scores_gemma":[0.9999324,0.000009614983,0.0000190824,0.000003951947,0.000008096094,0.00002678678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008155348,0.00009738938,0.003213029,0.0001972657,0.00004182454,0.0008529921,0.00008170018,0.00144559,0.9885064,0.001032174,0.0006926283,0.003023435],"study_design_scores_gemma":[0.0001961059,0.0003206127,0.06782542,0.00004396209,0.00008437079,0.001767371,0.0002322246,0.0337845,0.8874255,0.0008994875,0.007374749,0.00004560926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941229,0.001100893,0.002314644,0.0001512231,0.00004118849,0.00001748138,0.000411886,0.00009069373,0.001749055],"genre_scores_gemma":[0.9970642,0.0001750416,0.00113434,0.00006317527,0.00000483208,0.000009362078,0.0005199717,0.000009869766,0.001019194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005204559,"threshold_uncertainty_score":0.01417696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01691346936024469,"score_gpt":0.2225099325784188,"score_spread":0.2055964632181741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}