{"id":"W2060239414","doi":"10.1016/j.bbagrm.2010.01.005","title":"Estrogen receptor-dependent regulation of CYP2B6 in human breast cancer cells","year":2010,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Gene knockdown; Chromatin immunoprecipitation; Estrogen receptor; Estrogen receptor alpha; Coactivator; Nuclear receptor; Biology; Cancer research; Transcription factor; Transcriptional regulation; Breast cancer; Molecular biology; Gene expression; Gene; Cancer; Promoter; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002028906,0.0002075001,0.0003933106,0.0004723834,0.0003579971,0.0005705984,0.0001896295,0.0002041547,0.003844647],"category_scores_gemma":[0.0001959641,0.0002560904,0.0004433589,0.0006681236,0.0002260286,0.0001966891,0.0001983704,0.000485209,0.001578133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004692954,"about_ca_system_score_gemma":0.0002241944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003540274,"about_ca_topic_score_gemma":0.003616951,"domain_scores_codex":[0.9997224,0.00007508876,0.0000233942,0.00004419282,0.00007741125,0.00005742499],"domain_scores_gemma":[0.999864,0.00003931988,0.00001309491,0.00003293429,0.00003094363,0.00001965127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000492989,0.00007144372,0.0006118647,0.00004989954,0.00001368881,0.0001045963,0.00006966013,0.0000614258,0.9955884,0.0002578184,0.0003841746,0.002294078],"study_design_scores_gemma":[0.00005160431,0.0002099081,0.02748319,0.000007164942,0.00002674211,0.0005146373,0.0001140832,0.0009489961,0.9586688,0.000111424,0.01185433,0.000009053889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758964,0.009700106,0.003316699,0.0007323942,0.0001465547,0.00006063882,0.004377586,0.0002363707,0.005533143],"genre_scores_gemma":[0.9753587,0.003485677,0.00177749,0.0001190829,0.00003848929,0.0000609843,0.005900576,0.00005738344,0.01320162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003844647,"threshold_uncertainty_score":0.01286161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004886488080081482,"score_gpt":0.2347928928758745,"score_spread":0.229906404795793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}