{"id":"W2060275730","doi":"10.1038/nature07397","title":"Activating mutations in ALK provide a therapeutic target in neuroblastoma","year":2008,"lang":"en","type":"article","venue":"Nature","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":892,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pediatric Oncology Group","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute","keywords":"Neuroblastoma; Anaplastic lymphoma kinase; Cancer research; Biology; Gene knockdown; Molecular biology; Small hairpin RNA; Mutation; Tyrosine kinase; Cell culture; Gene; Signal transduction; Cell biology; Genetics; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002761045,0.000237903,0.0003518558,0.0004076265,0.0003760555,0.0007461047,0.0002813608,0.0006018609,0.004588241],"category_scores_gemma":[0.0002760023,0.0001883223,0.0002168354,0.0003302752,0.0003659965,0.0008309329,0.0004318303,0.00101192,0.001217126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004922342,"about_ca_system_score_gemma":0.0005015231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004014954,"about_ca_topic_score_gemma":0.001202023,"domain_scores_codex":[0.9999106,0.00001476043,0.000007597242,0.000009259657,0.00003385043,0.00002384004],"domain_scores_gemma":[0.9999373,0.00001534135,0.000009836991,0.000005855987,0.0000147547,0.000016873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00233543,0.0003887152,0.006485566,0.0008191774,0.00009769609,0.002546925,0.0002883011,0.003490422,0.4576048,0.04908098,0.04148232,0.4353796],"study_design_scores_gemma":[0.0009231537,0.002543636,0.01336157,0.0002519897,0.0005354549,0.01498735,0.0008818696,0.003854244,0.3117636,0.03587852,0.6149504,0.0000681743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5738459,0.2121646,0.01398654,0.05682081,0.003644121,0.0001746447,0.0009374066,0.0007492701,0.1376767],"genre_scores_gemma":[0.8811078,0.07719825,0.006271728,0.003506807,0.001119426,0.00006296824,0.0004032268,0.00008439504,0.0302454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004588241,"threshold_uncertainty_score":0.01534921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01921542182137839,"score_gpt":0.3121136169284821,"score_spread":0.2928981951071037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}