{"id":"W2060303574","doi":"10.1371/journal.pone.0015264","title":"Natural Variation of the Amino-Terminal Glutamine-Rich Domain in Drosophila Argonaute2 Is Not Associated with Developmental Defects","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; Japan Society for the Promotion of Science; Biotechnology and Biological Sciences Research Council; Terry Fox Foundation; Directorate for Biological Sciences; National Institutes of Health; European Commission; Alnylam Pharmaceuticals; Commonwealth of Massachusetts; Deutsche Forschungsgemeinschaft; University of Dundee; Wellcome Trust; Burroughs Wellcome Fund","keywords":"Biology; RNA interference; Argonaute; Genetics; Gene silencing; Drosophila melanogaster; Null allele; Genetic screen; Gene isoform; Gene; Allele; Cell biology; Mutant; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009564182,0.0003391441,0.0002050884,0.0002645439,0.0001531938,0.0001574914,0.000273772,0.0003193019,0.001677417],"category_scores_gemma":[0.0001818133,0.0001657778,0.0002424001,0.0001384323,0.0003247227,0.0001003233,0.0002535675,0.0004178115,0.0003624724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002000451,"about_ca_system_score_gemma":0.0001355404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003381425,"about_ca_topic_score_gemma":0.0009575585,"domain_scores_codex":[0.9998168,0.00002754448,0.00002445604,0.00006756368,0.00004810825,0.0000155247],"domain_scores_gemma":[0.9996532,0.00008125656,0.0001276325,0.00004757197,0.00001484405,0.00007540684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005557961,0.00001154597,0.0003444878,0.00001298609,0.000009889526,0.0001540612,0.000005148573,0.00002385303,0.9988918,0.00004837894,0.00001740152,0.0004248896],"study_design_scores_gemma":[0.00006057681,0.0003726504,0.06360293,0.00001124845,0.0000711129,0.006834036,0.00004120529,0.001622703,0.9219103,0.0001710215,0.00527784,0.0000243772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962359,0.0004335287,0.001879545,0.00005080123,0.00002166205,0.00001359018,0.0005347331,0.00007446192,0.0007557634],"genre_scores_gemma":[0.9966893,0.0001336032,0.001150291,0.00004293629,0.000007060224,0.00001788259,0.000837328,0.00004570296,0.001076041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001677417,"threshold_uncertainty_score":0.005611539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01265490213071775,"score_gpt":0.2195775500224756,"score_spread":0.2069226478917579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}