{"id":"W2060320557","doi":"10.7895/ijadr.v2i3.72","title":"Inhibition of cholinergic muscarinic signaling by ethanol: Potential mechanism of developmental neurotoxicity and biological plausibility for the beneficial effects of choline supplementation","year":2013,"lang":"en","type":"article","venue":"The International Journal of Alcohol and Drug Research","topic":"Prenatal Substance Exposure Effects","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Alcohol Abuse and Alcoholism","keywords":"Muscarinic acetylcholine receptor; Neurotoxicity; Acetylcholine; Cholinergic; Neuroscience; Cholinergic neuron; Signal transduction; Biology; Chemistry; Cell biology; Pharmacology; Receptor; Biochemistry; Toxicity","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002112765,0.00007614901,0.000217664,0.0001508903,0.00004204679,0.00001370494,0.0001678562,0.00004704027,0.00002373008],"category_scores_gemma":[0.0005997031,0.000042665,0.00006584611,0.0001100834,0.0001936582,0.0001122859,0.0001197536,0.0002756176,1.630425e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004629391,"about_ca_system_score_gemma":0.00007035962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001765919,"about_ca_topic_score_gemma":0.00001667638,"domain_scores_codex":[0.9983932,0.0001758497,0.0005089875,0.0001129835,0.0006792819,0.0001296401],"domain_scores_gemma":[0.9976944,0.00132976,0.0002626085,0.00006205559,0.0006063824,0.0000448457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001328,0.0001964295,0.002872267,0.0001036101,0.00009026041,0.000005845754,0.000578901,0.00004436676,0.9913346,0.0001989824,0.00007507022,0.003171656],"study_design_scores_gemma":[0.003572539,0.0005838514,0.03861471,0.0002158802,0.00002227186,0.00005065515,0.0003564848,0.001088886,0.9528003,0.002652626,0.000003620454,0.00003812085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971528,0.0003242666,0.0004510809,0.001118849,0.0001035617,0.0008113655,0.00002548689,0.00000145814,0.00001112754],"genre_scores_gemma":[0.9992915,0.0002530657,0.0002630803,0.00003952388,0.0001028053,0.00002477402,0.00001324608,0.000005426574,0.000006627865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03853425,"threshold_uncertainty_score":0.1739828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04147697052970203,"score_gpt":0.3449240722630046,"score_spread":0.3034471017333026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}