{"id":"W2060337978","doi":"10.1074/jbc.m106659200","title":"Identification of Sites in the Second Exomembrane Loop and Ninth Transmembrane Helix of the Mammalian Na+/H+ Exchanger Important for Drug Recognition and Cation Translocation","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Chromosomal translocation; Transmembrane protein; Identification (biology); Chemistry; Drug; Transmembrane domain; Loop (graph theory); Biophysics; Biology; Biochemistry; Pharmacology; Membrane; Botany; Gene; Receptor; Combinatorics; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001338307,0.000267847,0.0002396857,0.0001094351,0.0001012098,0.0001853312,0.0001877253,0.0003528007,0.0005955049],"category_scores_gemma":[0.0002060958,0.00009750495,0.0003033824,0.0000740648,0.000184693,0.0001680266,0.0001905081,0.0002831414,0.0003288274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001608716,"about_ca_system_score_gemma":0.0002153234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003748131,"about_ca_topic_score_gemma":0.0003847209,"domain_scores_codex":[0.9999187,0.00001432642,0.00001029498,0.00002299889,0.00002021441,0.00001342747],"domain_scores_gemma":[0.9997864,0.00003341093,0.00009285295,0.00001662764,0.00001364855,0.00005704351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003182786,0.00002122423,0.001335053,0.00003404367,0.000004995638,0.000146253,0.00001589277,0.0001008957,0.996628,0.00007094971,0.00001296085,0.001311434],"study_design_scores_gemma":[0.0000627321,0.0007527913,0.05918944,0.00001477473,0.00005101066,0.002014217,0.0000530598,0.00202761,0.933715,0.00009953457,0.002003654,0.00001606638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967546,0.0003881497,0.002309697,0.00003435053,0.00001089529,0.00002566859,0.000138786,0.00001461434,0.000323141],"genre_scores_gemma":[0.9931919,0.0002474029,0.005445645,0.00003389836,0.000009102273,0.00001980954,0.0004729368,0.000005568223,0.0005737153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005955049,"threshold_uncertainty_score":0.001992166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02844562456193383,"score_gpt":0.2475676332144485,"score_spread":0.2191220086525147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}